Laboratório de Farmacologia, Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, Brazil.
Neurosci Lett. 2013 Oct 11;553:110-4. doi: 10.1016/j.neulet.2013.08.026. Epub 2013 Aug 21.
The research on sex differences in nociception and antinociception as well as sex and gender differences in pain and analgesia is a maturing field. There is a vast literature showing experimental and clinical pain suppressive effects induced by minocycline, especially in inflammatory pain. However, as far as we know, possible qualitative or quantitative sex differences in those effects remained to be examined. By employing the formalin test, which has two phases of experimental pain behavior that models nociceptive pain (i.e., first phase) and inflammatory pain (i.e., second phase), we initially evaluated the effect induced by minocycline in female or male C57BL/6 mice. The treatment reduced the second phase of licking behavior in both females and males, and the effects were quantitatively similar in both sexes. Likewise, the same sex-independent effect was observed in Swiss mice, suggesting a genotype-unspecific sex-independent effect. While minocycline is already being tested in clinical trials, this appears to be the first preclinical investigation of sex differences in the experimental pain suppressive effects induced by this widely studied drug. The independence of sex in the antinociceptive effect induced by minocycline may be hopefully translated to gender-independent analgesic effects, which would be surely promising in a therapeutic paradigm.
痛觉和抗痛觉的性别差异以及疼痛和镇痛的性别差异研究是一个不断发展的领域。有大量文献表明，米诺环素具有实验性和临床疼痛抑制作用，尤其是在炎症性疼痛中。然而，据我们所知，这种作用可能存在定性或定量的性别差异，需要进一步研究。我们采用福尔马林测试，该测试有两个实验性疼痛行为阶段，模拟伤害性疼痛（即第一阶段）和炎症性疼痛（即第二阶段），最初评估了米诺环素在雌性或雄性 C57BL/6 小鼠中诱导的效果。该治疗方法减少了雌性和雄性动物的第二阶段舔舐行为，并且在两种性别中的效果在数量上相似。同样，在瑞士小鼠中也观察到相同的性别独立性效应，表明这种效应与基因型无关，具有性别独立性。虽然米诺环素已经在临床试验中进行了测试，但这似乎是首次对这种广泛研究的药物诱导的实验性疼痛抑制作用中的性别差异进行的临床前研究。米诺环素诱导的抗痛觉作用的性别独立性可能有望转化为性别独立性的镇痛作用，这在治疗模式中肯定是有希望的。
