Nek8 将肾脏纤毛病与 DNA 损伤和检查点控制联系起来。
Nek8 couples renal ciliopathies to DNA damage and checkpoint control.
机构信息
Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Mol Cell. 2013 Aug 22;51(4):407-8. doi: 10.1016/j.molcel.2013.08.013.
PMID:23973371
Abstract
In this issue, Choi et al. (2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration.
摘要
在本期中，Choi 等人（2013 年）发现了 Nek8 激酶与 cyclin A/Cdk2 和 ATR-Chk1 对 DNA 损伤控制之间的分子联系，该激酶在肾脏纤毛病肾单位肾病变中发生突变，为限制组织退化的靶向治疗提供了新的思路。
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