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分析采用保留肛提肌的经腹会阴直肠肛门切除术的治疗效果。并非所有患者均有必要行柱状 ELAPE。

Analysis of outcome using a levator sparing technique of abdominoperineal excision of rectum and anus. Cylindrical ELAPE is not necessary in all patients.

机构信息

Aberdeen Royal Infirmary, Colorectal Department, Aberdeen AB252ZN, United Kingdom.

出版信息

Eur J Surg Oncol. 2013 Nov;39(11):1219-24. doi: 10.1016/j.ejso.2013.08.004. Epub 2013 Aug 20.

Abstract

AIMS

Abdominoperineal excision of rectum (APE) for cancer has a higher rate of local recurrence with a poorer outcome than stage matched anterior resection. The cylindrical excision (ELAPE) has been advocated to reduce local recurrence. However, this operation has greater morbidity and requires more post operative care. We report our outcomes from a single centre using a levator sparing dissection.

METHODS

All patients undergoing APE from January 2007-June 2011 were evaluated. Case notes operation notes and pathology results were reviewed for complications and staging. Follow-up data for survival and recurrence were obtained from the cancer registry, imaging and from clinic follow up.

RESULTS

Of all rectal cancers (n = 361), 43 had APE with curative intent. Median age was 67(IQR 59-76). Median tumour height was two centimetres from the dentate line (IQR 1-3.5 cm). Neoadjuvant chemoradiotherapy was given in 98% of APE resections with curative intent. Median post operative hospital stay was 10 days (8-15). At a median follow up of 38 months (IQR30-49) for patients undergoing curative resection, 2 patients (4.6%) had local recurrence and overall mortality was 18.6% (n = 8).

CONCLUSION

With adequate neoadjuvant chemoradiotherapy, a levator sparing excision of rectum remains a safe option with less morbidity and perioperative complications than has been described for ELAPE.

摘要

目的

与匹配分期的前切除术相比,肛门直肠切除术(APE)治疗癌症的局部复发率更高,预后更差。为了降低局部复发率,已经提倡采用圆柱切除(ELAPE)。然而,这种手术的发病率更高,术后需要更多的护理。我们报告了我们在一个中心使用保留提肌解剖的单一中心的结果。

方法

评估了 2007 年 1 月至 2011 年 6 月期间所有接受 APE 的患者。查阅病例记录、手术记录和病理结果,以评估并发症和分期。通过癌症登记处、影像学和临床随访获得生存和复发的随访数据。

结果

在所有直肠癌(n=361)中,43 例患者接受了 APE 根治性治疗。中位年龄为 67 岁(IQR59-76)。中位肿瘤距齿状线高度为 2 厘米(IQR1-3.5 厘米)。98%接受 APE 根治性切除术的患者接受了新辅助放化疗。术后中位住院时间为 10 天(8-15)。在中位随访 38 个月(IQR30-49)时,2 名(4.6%)患者出现局部复发,总死亡率为 18.6%(n=8)。

结论

在充分的新辅助放化疗的情况下,与 ELAPE 相比,保留提肌的直肠切除仍然是一种安全的选择,发病率和围手术期并发症较少。

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