Thurston C L, Randich A
Department of Psychology, University of Iowa, Iowa City 52242.
Brain Res. 1990 Jun 11;519(1-2):12-22. doi: 10.1016/0006-8993(90)90055-g.
Occlusion of the abdominal aorta proximal to the renal arteries results in an increase in arterial blood pressure, inhibition of forepaw and hindpaw withdrawal to a noxious mechanical stimulus, and inhibition of the tail-flick reflex to noxious heat. Occlusion of the abdominal aorta distal to the renal arteries does not elevate arterial blood pressure and produces no antinociceptive effects. Occlusion of the vena cava lowers arterial blood pressure and produces no antinociception. The inhibitory effects of occlusion of the abdominal aorta depend upon activation of high pressure baroreceptors since bilateral sinoaortic denervation, but not bilateral vagotomy, eliminates the inhibition with respect to all behavioral measures. The inhibitory effects with respect to the tail-flick reflex also depend upon activation of a descending inhibitory system since reversible cold block of the spinal cord at the level of the second thoracic vertebra eliminates the antinociception. This antinociception is also eliminated following intrathecal administration of the noradrenergic receptor antagonist phentolamine, but not by intrathecal administration of either methysergide or naloxone. These data support the view that activation of high pressure baroreceptors by increases in arterial blood pressure produces antinociception via activation of a spinopetal noradrenergic system.
肾动脉近端的腹主动脉闭塞会导致动脉血压升高、抑制前爪和后爪对有害机械刺激的退缩反应以及抑制对有害热刺激的甩尾反射。肾动脉远端的腹主动脉闭塞不会升高动脉血压，也不会产生任何抗伤害感受作用。腔静脉闭塞会降低动脉血压，且不产生抗伤害感受作用。腹主动脉闭塞的抑制作用取决于高压压力感受器的激活，因为双侧窦神经切除而非双侧迷走神经切断会消除所有行为指标的抑制作用。对甩尾反射的抑制作用也取决于下行抑制系统的激活，因为在第二胸椎水平对脊髓进行可逆性冷阻滞会消除抗伤害感受作用。鞘内注射去甲肾上腺素能受体拮抗剂酚妥拉明后，这种抗伤害感受作用也会消除，但鞘内注射麦角新碱或纳洛酮则不会。这些数据支持这样一种观点，即动脉血压升高激活高压压力感受器通过激活向心性去甲肾上腺素能系统产生抗伤害感受作用。
