最薄弱环节：稳定整合素-肌动蛋白连接的新范式。 - Suppr

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The weakest link: a new paradigm for stabilizing the integrin-actin connection.

作者信息

Morgner Jessica, Wickström Sara A

机构信息

Paul Gerson Unna Group "Skin Homeostasis and Ageing"; Max Planck Institute for Biology of Ageing; Cologne, Germany.

出版信息

Cell Cycle. 2013 Sep 15;12(18):2929-30. doi: 10.4161/cc.26213. Epub 2013 Aug 23.

DOI:10.4161/cc.26213

PMID:23974089

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3875664/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b7/3875664/daeab16297bf/cc-12-2929-g1.jpg

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Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2):a005116. doi: 10.1101/cshperspect.a005116.

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins.

EMBO Rep. 2011 Mar;12(3):259-66. doi: 10.1038/embor.2011.5. Epub 2011 Feb 11.

HSP90 at the hub of protein homeostasis: emerging mechanistic insights.

Nat Rev Mol Cell Biol. 2010 Jul;11(7):515-28. doi: 10.1038/nrm2918. Epub 2010 Jun 9.

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24.

The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions.

Mol Cell. 2009 Dec 11;36(5):819-30. doi: 10.1016/j.molcel.2009.11.028.

The extracellular matrix: not just pretty fibrils.

Science. 2009 Nov 27;326(5957):1216-9. doi: 10.1126/science.1176009.

Integrin-linked kinase is an adaptor with essential functions during mouse development.

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The weakest link: a new paradigm for stabilizing the integrin-actin connection.

作者信息

Morgner Jessica, Wickström Sara A

机构信息

Paul Gerson Unna Group "Skin Homeostasis and Ageing"; Max Planck Institute for Biology of Ageing; Cologne, Germany.

出版信息

Cell Cycle. 2013 Sep 15;12(18):2929-30. doi: 10.4161/cc.26213. Epub 2013 Aug 23.

DOI:10.4161/cc.26213

PMID:23974089

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3875664/

Abstract

摘要

相似文献

The weakest link: a new paradigm for stabilizing the integrin-actin connection.

Cell Cycle. 2013 Sep 15;12(18):2929-30. doi: 10.4161/cc.26213. Epub 2013 Aug 23.

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.

EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23.

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.

Oncogene. 2012 Mar 22;31(12):1582-91. doi: 10.1038/onc.2011.342. Epub 2011 Aug 22.

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2897-902. doi: 10.1073/pnas.0810123106. Epub 2009 Feb 5.

Stabilization of integrin-linked kinase by binding to Hsp90.

Biochem Biophys Res Commun. 2005 Jun 17;331(4):1061-8. doi: 10.1016/j.bbrc.2005.03.225.

Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.

PLoS One. 2009 Jun 17;4(6):e5949. doi: 10.1371/journal.pone.0005949.

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Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3622-7. doi: 10.1073/pnas.0709180105. Epub 2008 Feb 21.

Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility.

J Biol Chem. 2013 Jun 7;288(23):16308-16320. doi: 10.1074/jbc.M112.400978. Epub 2013 Apr 18.

HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation.

PLoS One. 2012;7(7):e41973. doi: 10.1371/journal.pone.0041973. Epub 2012 Jul 27.

Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein).

J Biol Chem. 2013 Mar 8;288(10):7158-68. doi: 10.1074/jbc.M112.436758. Epub 2013 Jan 23.

引用本文的文献

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Autophagy. 2018;14(3):465-486. doi: 10.1080/15548627.2017.1422850. Epub 2018 Mar 11.

Leukocyte integrin α4β7 associates with heat shock protein 70.

Mol Cell Biochem. 2015 Nov;409(1-2):263-9. doi: 10.1007/s11010-015-2530-z. Epub 2015 Aug 11.

Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts.

PLoS One. 2014 Apr 7;9(4):e93921. doi: 10.1371/journal.pone.0093921. eCollection 2014.

本文引用的文献

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.

EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23.

Genetic analyses of integrin signaling.

Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2):a005116. doi: 10.1101/cshperspect.a005116.

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins.

EMBO Rep. 2011 Mar;12(3):259-66. doi: 10.1038/embor.2011.5. Epub 2011 Feb 11.

HSP90 at the hub of protein homeostasis: emerging mechanistic insights.

Nat Rev Mol Cell Biol. 2010 Jul;11(7):515-28. doi: 10.1038/nrm2918. Epub 2010 Jun 9.

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24.

The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions.

Mol Cell. 2009 Dec 11;36(5):819-30. doi: 10.1016/j.molcel.2009.11.028.

The extracellular matrix: not just pretty fibrils.

Science. 2009 Nov 27;326(5957):1216-9. doi: 10.1126/science.1176009.

Integrin-linked kinase is an adaptor with essential functions during mouse development.

Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.