眼见为实：被困于与其DNA装载蛋白形成的复合物中的MCM2-7解旋酶。 - Suppr

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超能文献

Seeing is believing: the MCM2-7 helicase trapped in complex with its DNA loader.

作者信息

Riera Alberto, Li Huilin, Speck Christian

机构信息

DNA Replication Group; MRC Clinical Sciences Centre; Imperial College; London, UK.

出版信息

Cell Cycle. 2013 Sep 15;12(18):2917-8. doi: 10.4161/cc.26132. Epub 2013 Aug 21.

DOI:10.4161/cc.26132

PMID:23974098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3875658/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef60/3875658/d2a444cf7394/cc-12-2917-g1.jpg

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本文引用的文献

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An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.一个 ORC/Cdc6/MCM2-7 复合物通过多步反应形成，作为 MCM 双六聚体组装的平台。

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.

ATPase-dependent quality control of DNA replication origin licensing.ATP 依赖的 DNA 复制起始许可的质量控制。

Nature. 2013 Mar 21;495(7441):339-43. doi: 10.1038/nature11920. Epub 2013 Mar 10.

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.一个双六聚体 MCM2-7 复合物在真核生物 DNA 复制的许可过程中被加载到起始 DNA 上。

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20240-5. doi: 10.1073/pnas.0911500106. Epub 2009 Nov 12.

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.在DNA复制起点许可过程中，Mcm2-7双六聚体围绕DNA的协同装载。

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The Mcm2-7 complex has in vitro helicase activity.Mcm2 - 7复合物具有体外解旋酶活性。

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