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药物基因组学:试错医学的终结?

Pharmacogenomics: The End of Trial-and-Error Medicine?

作者信息

Vail Jane

机构信息

St.Louis, Missouri.

出版信息

Int J Pharm Compd. 2007 Jan-Feb;11(1):59-65.

Abstract

"The right dose of the right drug for the right indication for the right patient at the right time." In those words, Dr.Felix Frueh captured the essence of pharmacogenomics and the goal of all compounding pharmacists. Pharmacogenomics provides the tools for prescribing personalized drug therapy that will improve treatment outcomes, decrease the incidence of drug-related adverse effects, and ultimately reduce the cost of medical care. The use of pharmacogenomics in clinical practice is changing as new discoveries make it possible and cost-effective to identify a patient's unique genetic makeup and apply this information to treating medical ailments. With a prescription and the patient's pharmacogenomic profile in mind, a compounding pharmacist can prepare a customized medication that delivers that patient's unique best dosage in the optimal dosage form.

摘要

“在正确的时间,为正确的患者,针对正确的适应症,给予正确剂量的正确药物。”费利克斯·弗吕博士的这番话抓住了药物基因组学的精髓以及所有配方药剂师的目标。药物基因组学提供了开出处方个性化药物治疗的工具,这将改善治疗效果,降低药物相关不良反应的发生率,并最终降低医疗成本。随着新发现使得识别患者独特的基因构成并将这些信息应用于治疗疾病成为可能且具有成本效益,药物基因组学在临床实践中的应用正在发生变化。考虑到处方和患者的药物基因组概况,配方药剂师可以配制出定制药物,以最佳剂型提供该患者独特的最佳剂量。

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