Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, 48201, USA,
Indian J Pediatr. 2013 Oct;80(10):863-9. doi: 10.1007/s12098-013-1106-8. Epub 2013 Aug 24.
Hodgkin lymphoma in children is a highly curable malignancy with current approaches utilizing combined modality therapy and a risk-adapted approach. The combination of anthracyclines, bleomycin, and radiotherapy, as well as other alkylating agents, are significant risk factors for secondary malignancies and cardiopulmonary toxicity. Therefore, current strategies aim to optimize cure rates while minimizing late effects. The role of radiotherapy has been examined in recent pediatric trials, with varying results. However, they provide evidence, as a whole, for the omission of radiotherapy for a subgroup of patients, without compromising outcomes.
儿童霍奇金淋巴瘤是一种高度可治愈的恶性肿瘤，目前采用联合治疗方法和风险适应方法。蒽环类药物、博来霉素和放疗的联合应用，以及其他烷化剂，是导致继发性恶性肿瘤和心肺毒性的重要危险因素。因此，目前的策略旨在优化治愈率，同时最大限度地减少晚期效应。放疗在最近的儿科试验中得到了检验，结果不尽相同。然而，它们提供了整体证据，证明在不影响结果的情况下，可以免除一部分患者的放疗。
