BLT2 是癌症进展过程中的促肿瘤发生介质，也是开发抗癌药物的治疗靶点。
BLT2 is a pro-tumorigenic mediator during cancer progression and a therapeutic target for anti-cancer drug development.
机构信息
College of Life Sciences and Biotechnology, Korea University Seoul 136-701, Korea.
出版信息
Am J Cancer Res. 2013 Aug 14;3(4):347-55. eCollection 2013.
Abstract
Cancer is a leading cause of death worldwide and has been linked to inflammation. Leukotriene B4 (LTB4) is synthesized from arachidonic acid via the 5-lipoxygenase pathway and is a potent chemoattractant for inflammatory cells. LTB4 was recently shown to be associated with the pathogenesis of inflammatory diseases, including cancer. Of the two known LTB4 receptors, BLT1 and BLT2, the biological roles of the low-affinity LTB4 receptor 2, BLT2, have only recently been elucidated. This review focuses on recent discoveries regarding BLT2 and its roles in cancer progression and the downstream signaling mechanisms of the BLT2-linked signaling cascade in cancer cells. We believe that these findings will facilitate the development of new cancer treatments.
摘要
癌症是全球主要死因之一，与炎症有关。白三烯 B4（LTB4）是通过 5-脂氧合酶途径从花生四烯酸合成的，是炎症细胞的有效趋化因子。最近的研究表明，LTB4 与炎症性疾病的发病机制有关，包括癌症。在两种已知的 LTB4 受体 BLT1 和 BLT2 中，低亲和力 LTB4 受体 2（BLT2）的生物学作用最近才被阐明。本综述重点介绍了 BLT2 的最新发现及其在癌症进展中的作用，以及癌症细胞中 BLT2 相关信号级联的下游信号机制。我们相信这些发现将有助于开发新的癌症治疗方法。
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