Divisions of Cardiovascular and Thoracic Surgery;
Ann Cardiothorac Surg. 2012 Sep;1(3):311-9. doi: 10.3978/j.issn.2225-319X.2012.08.13.
Thoracoabdominal aortic aneurysms (TAAA) remain amongst the most formidable of surgical challenges, particularly degenerative aneurysms in the elderly population with concomitant pulmonary disease. This report presents an update of our robust single-institution experience with "hybrid" TAAA repair including complete visceral debranching and endovascular aneurysm exclusion in high-risk patients.
Between March 2005 and June 2012, 58 patients underwent extra-anatomic debranching of all visceral vessels followed by aneurysm exclusion via endovascular means at a single institution. The median number of visceral vessels bypassed was 4. The debranching and endovascular portions of the procedure were performed as a single stage in the initial 33 patients and as a staged approach in the most recent n=25 cases.
Median patient age was 69.0 years; 50% were female. All had significant co-morbidity and were considered suboptimal candidates for conventional open surgical repair. Mean aortic diameter was 6.7¡À1.2 cm. Thirty-day/in-hospital rates of death, stroke, and permanent paraparesis/paraplegia were 9%, 0%, and 4%, respectively; in the most recent 25 patients undergoing staged repair these rates were 4%, 0%, and 0%. Over a mean follow-up of 26¡À21 months, visceral graft patency is 95.3%; all occluded limbs were to renal vessels and none resulted in permanent dialysis. Two patients (3%) have required re-intervention, one for type Ib and one for type III endoleak. Five-year freedom from re-intervention was 94%. Kaplan-Meier overall survival was 78% at 1 year and 62% at 5 years, with a 5-year aorta-specific survival of 87%.
These updated results continue to support hybrid TAAA repair via complete visceral debranching and endovascular aneurysm exclusion as a good option for elderly high-risk patients less suited to conventional open repair. A staged approach to debranching and endovascular aneurysm exclusion appears to yield optimal results.
胸主动脉腹主动脉瘤(TAAA)仍然是最具挑战性的手术之一,特别是在老年人群中,伴有肺部疾病的退行性动脉瘤。本报告介绍了我们在高危患者中进行“杂交”TAAA 修复的丰富单机构经验,包括完全内脏去分支和血管内动脉瘤排除。
在 2005 年 3 月至 2012 年 6 月期间,58 例患者在一家机构接受了所有内脏血管的解剖外去分支,然后通过血管内方法排除了动脉瘤。绕过的内脏血管中位数为 4 条。在最初的 33 例患者中,去分支和血管内部分是作为一个阶段进行的,而在最近的 n=25 例患者中,是作为一个阶段进行的。
中位患者年龄为 69.0 岁;50%为女性。所有患者均有严重的合并症,被认为不适合传统的开放手术修复。平均主动脉直径为 6.7¡À1.2cm。30 天/住院死亡率、中风率和永久性截瘫/截瘫率分别为 9%、0%和 4%;在最近接受分期修复的 25 例患者中,这些比率分别为 4%、0%和 0%。在平均 26¡À21 个月的随访中,内脏移植物通畅率为 95.3%;所有闭塞的肢体均为肾血管,无一例导致永久性透析。有 2 例患者(3%)需要再次介入治疗,1 例为 Ib 型,1 例为 III 型内漏。5 年免于再次干预的比例为 94%。Kaplan-Meier 总体生存率为 1 年时为 78%,5 年时为 62%,5 年时的主动脉特异性生存率为 87%。
这些更新的结果继续支持通过完全内脏去分支和血管内动脉瘤排除进行杂交 TAAA 修复,作为不适合传统开放修复的老年高危患者的一种较好选择。去分支和血管内动脉瘤排除的分期方法似乎可以获得最佳结果。