Hughes G Chad, Nienaber Jeffrey J, Bush Errol L, Daneshmand Mani A, McCann Richard L
Division of Thoracic & Cardiovascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
J Thorac Cardiovasc Surg. 2008 Jul;136(1):21-8, 28.e1-6. doi: 10.1016/j.jtcvs.2008.02.051. Epub 2008 May 7.
A significant number of patients with thoracic and thoracoabdominal aortic aneurysms are unsuitable for endovascular repair owing to the absence of graft seal zones. "Hybrid" techniques, including open aortic debranching procedures, allow creation of proximal and/or distal landing zones and expand the potential applications of endovascular repair. We report our experience with aortic arch and thoracoabdominal debranching using custom fabricated Dacron branch grafts, which greatly simplify aortic debranching by providing inflow via a single anastomosis and incorporate a side arm for introduction of the stent graft.
Between November 14, 2005, and December 18, 2006, a total of 53 thoracic endograft procedures were performed at our institution. Of these, 13 (25%) involved either open aortic arch or abdominal debranching to create proximal or distal landing zones for endovascular repair. Patients undergoing arch debranching (n = 7) had aneurysms involving the transverse arch with less than 2 cm of proximal landing zone distal to the innominate artery, necessitating stent graft coverage of both the innominate and left common carotid arteries. Patients undergoing complete abdominal debranching (n = 6) had either thoracoabdominal aortic aneurysms (extent II, n = 1; extent V, n = 3) or visceral button false aneurysms after prior open thoracoabdominal aortic aneurysm repair (n = 2). In all cases, endovascular aneurysm exclusion was performed at the same operation.
Mean patient age was 63 +/- 11 years (range 46-83 years); all patients had significant comorbidities, including prior open aortic surgery in 8 (62%). There were no perioperative (30 day) deaths and no permanent neurologic deficits, either cerebrovascular accident or paraparesis/paraplegia. At a mean follow-up of 7.5 +/- 6.0 months, there has been no late mortality and all debranching bypass grafts remain patent without need for further intervention. Computed tomographic scans demonstrate no type I or III endoleaks, and all aneurysms are thrombosed with stable (n = 4) or decreasing aortic dimensions (n = 9).
"Hybrid" aortic debranching using custom fabricated Dacron branch grafts with a single inflow source combined with endovascular aneurysm exclusion appears to be a safe alternative to conventional open repair for thoracoabdominal and arch aneurysms and avoids the need for cardiopulmonary bypass and aortic crossclamping. This technique may be ideally suited to patients with significant comorbidity or prior open aortic surgery. Longer term follow-up is needed to determine the durability of this approach.
相当一部分胸主动脉和胸腹主动脉瘤患者因缺乏移植物密封区而不适合进行血管腔内修复。“杂交”技术,包括开放性主动脉去分支手术,可创建近端和/或远端着陆区,并扩大血管腔内修复的潜在应用范围。我们报告了使用定制的涤纶分支移植物进行主动脉弓和胸腹去分支的经验,该移植物通过单一吻合口提供血流,极大地简化了主动脉去分支,并并入一个侧臂用于引入支架移植物。
2005年11月14日至2006年12月18日期间,我们机构共进行了53例胸主动脉腔内修复手术。其中13例(25%)涉及开放性主动脉弓或腹部去分支,以创建血管腔内修复的近端或远端着陆区。接受弓部去分支的患者(n = 7),其动脉瘤累及横弓,无名动脉远端近端着陆区小于2 cm,需要对无名动脉和左颈总动脉进行支架移植物覆盖。接受完全腹部去分支的患者(n = 6),患有胸腹主动脉瘤(II型,n = 1;V型,n = 3)或先前开放性胸腹主动脉瘤修复术后的内脏纽扣状假性动脉瘤(n = 2)。在所有病例中,均在同一次手术中进行血管腔内动脉瘤排除术。
患者平均年龄为63±11岁(范围46 - 83岁);所有患者均有严重的合并症,其中8例(62%)曾接受过开放性主动脉手术。围手术期(30天)无死亡病例,也无永久性神经功能缺损,包括脑血管意外或轻瘫/截瘫。平均随访7.5±6.0个月,无晚期死亡病例,所有去分支旁路移植物均保持通畅,无需进一步干预。计算机断层扫描显示无I型或III型内漏,所有动脉瘤均血栓形成,主动脉尺寸稳定(n = 4)或缩小(n = 9)。
使用定制的具有单一血流来源的涤纶分支移植物进行“杂交”主动脉去分支,联合血管腔内动脉瘤排除术,对于胸腹主动脉瘤和弓部动脉瘤而言,似乎是一种安全的替代传统开放性修复的方法,并且避免了体外循环和主动脉阻断的需要。该技术可能非常适合有严重合并症或曾接受过开放性主动脉手术的患者。需要更长时间的随访来确定这种方法的耐久性。