代谢对低温诱导的豚鼠离体心房超敏反应的作用；对β-肾上腺素能受体激动剂及其正性肌力反应的选择性超敏反应。 - Suppr

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超能文献

The contribution of metabolism to the hypothermia-induced supersensitivity of guinea-pig isolated atria; selective supersensitivity for beta-adrenoceptor agonists and their positive inotropic responses.

作者信息

Broadley K J, Duncan C

出版信息

Gen Pharmacol. 1977;8(5-6):305-10. doi: 10.1016/0306-3623(77)90004-0.

DOI:10.1016/0306-3623(77)90004-0

PMID:23978

Abstract

摘要

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The contribution of metabolism to the hypothermia-induced supersensitivity of guinea-pig isolated atria; selective supersensitivity for beta-adrenoceptor agonists and their positive inotropic responses.代谢对低温诱导的豚鼠离体心房超敏反应的作用；对β-肾上腺素能受体激动剂及其正性肌力反应的选择性超敏反应。

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Responses mediated via beta 1, but not beta 2-adrenoceptors, exhibit hypothermia-induced supersensitivity.通过β1而非β2肾上腺素能受体介导的反应表现出低温诱导的超敏感性。

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Selective reserpine-induced supersensitivity of the positive inotropic and chronotropic responses to isoprenaline and salbutamol in guinea-pig isolated atria.利血平选择性诱导豚鼠离体心房对异丙肾上腺素和沙丁胺醇的正性肌力和变时反应超敏。

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Temperature-induced changes in dissociation constants (KA) of agonists at cardiac beta-adrenoceptors determined by use of the irreversible antagonist Ro 03-7894.利用不可逆拮抗剂Ro 03-7894测定温度诱导的激动剂在心脏β-肾上腺素能受体处解离常数（KA）的变化。

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引用本文的文献

Effects of hypothermia on pharmacokinetics and pharmacodynamics: a systematic review of preclinical and clinical studies.低温对药代动力学和药效学的影响：临床前和临床研究的系统评价。

Clin Pharmacokinet. 2010 May;49(5):277-94. doi: 10.2165/11319360-000000000-00000.

Br J Pharmacol. 1983 Jun;79(2):517-24. doi: 10.1111/j.1476-5381.1983.tb11026.x.

Dissociation constants of isoprenaline and orciprenaline and their relative efficacies on guinea-pig isolated atria determined by use of an irreversible beta-adrenoceptor antagonist.通过使用不可逆的β-肾上腺素能受体拮抗剂测定异丙肾上腺素和奥西那林的解离常数及其对豚鼠离体心房的相对效能。

Br J Pharmacol. 1981 Apr;72(4):635-43. doi: 10.1111/j.1476-5381.1981.tb09143.x.

Functional antagonism as a means of determining dissociation constants and relative efficacies of sympathomimetic amines in guinea-pig isolated atria.功能拮抗作用作为测定豚鼠离体心房中拟交感神经胺的解离常数和相对效能的一种方法。

Br J Pharmacol. 1979 Jul;66(3):397-404. doi: 10.1111/j.1476-5381.1979.tb10844.x.

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