Laboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, and Nanobiotechnology Division at University of Talca, Fraunhofer Chile Research Foundation - Center for Systems Biotechnology, FCR-CSB, P.O. Box 747, Talca, Chile.
Curr Top Med Chem. 2013;13(17):2184-99. doi: 10.2174/15680266113139990151.
Alkaloids are interesting groups of natural products with important biological properties, but naturally available alkaloids are insufficient for biological studies. Therefore, the demand for higher amounts of alkaloids made research community to synthesize alkaloids by innovative techniques. The importance of asymmetric reactions for scientific community to obtain enantiomerically pure compounds with good yield and diastereomeric excess (de) or enantiomeric excess (ee) by different strategies of asymmetric induction is emphasized in this review. In addition, importance have been given to discuss on biologically important alkaloids, their skeleton synthesis, intermediates and total synthesis with different strategies mainly based on chiral auxiliaries, chiral reagents and chiral metal ligand based catalysts.
生物碱是具有重要生物活性的一类有趣的天然产物，但可获得的天然生物碱数量不足以满足生物研究的需求。因此，对更多生物碱的需求促使研究人员通过创新技术来合成生物碱。本文综述了不对称反应对于科学界的重要性，通过不同的不对称诱导策略，该反应可以获得对映体纯的化合物，具有良好的产率和非对映体过量（de）或对映体过量（ee）。此外，本文还讨论了具有重要生物学意义的生物碱，它们的骨架合成、中间体和总合成，主要基于手性辅助剂、手性试剂和手性金属配体催化剂的不同策略。
