肾移植患者的供者相关性恶性肿瘤。
Donor-associated malignancy in kidney transplant patients.
机构信息
Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
出版信息
J Clin Invest. 2013 Sep;123(9):3708-9. doi: 10.1172/JCI70438. Epub 2013 Aug 27.
Abstract
Skin cancer cells with donor genotype have been identified in allogeneic transplant patients; however, the donor contribution to the recipient's epithelial malignancy remains to be established. In this issue of the JCI, Verneuil et al. provide the first evidence for donor contribution to the malignant epithelium of skin squamous cell carcinoma in a kidney transplant recipient. This case report may have important implications for cancer research and clinical care of long-surviving kidney transplant patients.
摘要
在同种异体移植患者中已鉴定出具有供体基因型的皮肤癌细胞；然而，供体对受者上皮恶性肿瘤的贡献仍有待确定。在本期 JCI 中，Verneuil 等人提供了首例证据，证明供体对肾移植受者皮肤鳞状细胞癌的恶性上皮有贡献。这一病例报告可能对癌症研究和长期存活的肾移植患者的临床护理具有重要意义。
相似文献
1
Donor-associated malignancy in kidney transplant patients.肾移植患者的供者相关性恶性肿瘤。
J Clin Invest. 2013 Sep;123(9):3708-9. doi: 10.1172/JCI70438. Epub 2013 Aug 27.
2
Human skin carcinoma arising from kidney transplant-derived tumor cells.肾移植来源的肿瘤细胞导致的人皮肤癌。
J Clin Invest. 2013 Sep;123(9):3797-801. doi: 10.1172/JCI66721. Epub 2013 Aug 27.
3
Transplantation: Donor-derived skin cancer in a kidney transplant recipient.移植：肾移植受者的供体来源皮肤癌。
Nat Rev Nephrol. 2013 Dec;9(12):702-3. doi: 10.1038/nrneph.2013.211. Epub 2013 Oct 8.
4
Donor-derived stem-cells and epithelial mesenchymal transition in squamous cell carcinoma in transplant recipients.移植受者鳞状细胞癌中供体来源的干细胞与上皮-间质转化
Oncotarget. 2015 Dec 8;6(39):41497-507. doi: 10.18632/oncotarget.6359.
5
Skin nodule on the ear of a kidney-pancreas transplant recipient.一位肾胰腺移植受者耳部的皮肤结节。
Am J Transplant. 2014 May;14(5):1217-9. doi: 10.1111/ajt.12538.
6
Excessive number of skin cancers in an Italian renal transplant recipient.一名意大利肾移植受者患皮肤癌数量过多。
Nephron. 2000 Feb;84(2):183-4. doi: 10.1159/000045567.
7
Awareness of skin cancer by kidney transplant patients.肾移植患者对皮肤癌的认知
J Am Acad Dermatol. 1999 May;40(5 Pt 1):697-701. doi: 10.1016/s0190-9622(99)70149-0.
8
Fatal squamous cell carcinoma arising from transplant-associated porokeratosis.移植相关汗孔角化症引发的致命性鳞状细胞癌。
J Am Acad Dermatol. 2003 Nov;49(5):931-3. doi: 10.1016/s0190-9622(03)00469-9.
9
Skin carcinoma arising from donor cells in a kidney transplant recipient.肾移植受者中源自供体细胞的皮肤癌
Cancer Res. 2005 Mar 1;65(5):1755-60. doi: 10.1158/0008-5472.CAN-04-2783.
10
Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells in a renal-pancreas transplant recipient.肾-胰腺移植受者中具有横纹肌样表型和破骨细胞样巨细胞的鳞状细胞癌
J Clin Pathol. 2006 Dec;59(12):1309-11. doi: 10.1136/jcp.2005.034991.
引用本文的文献
1
A retrospective single-center pilot study of the genetic background of the transplanted kidney.一项关于移植肾基因背景的回顾性单中心试点研究。
PLoS One. 2025 Jan 8;20(1):e0316192. doi: 10.1371/journal.pone.0316192. eCollection 2025.
2
5'-Cap‒Dependent Translation as a Potent Therapeutic Target for Lethal Human Squamous Cell Carcinoma.5'-Cap 依赖性翻译作为致命性人类鳞状细胞癌的有效治疗靶点。
J Invest Dermatol. 2021 Apr;141(4):742-753.e10. doi: 10.1016/j.jid.2020.08.021. Epub 2020 Sep 21.
本文引用的文献
1
Human skin carcinoma arising from kidney transplant-derived tumor cells.肾移植来源的肿瘤细胞导致的人皮肤癌。
J Clin Invest. 2013 Sep;123(9):3797-801. doi: 10.1172/JCI66721. Epub 2013 Aug 27.
2
Duration of brain death and cold ischemia time, but not warm ischemia time, increases expression of genes associated with apoptosis in transplanted kidneys from deceased donors.脑死亡持续时间和冷缺血时间，而非热缺血时间，会增加来自已故供体的移植肾中与细胞凋亡相关基因的表达。
Transplant Proc. 2011 Oct;43(8):2887-90. doi: 10.1016/j.transproceed.2011.08.013.
3
Identifying the cellular origin of squamous skin tumors.鉴定鳞状皮肤肿瘤的细胞起源。
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6. doi: 10.1073/pnas.1012720108. Epub 2011 Apr 18.
4
Universal noninvasive detection of solid organ transplant rejection.通用的无创性检测方法可用于诊断实体器官移植排斥反应。
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6229-34. doi: 10.1073/pnas.1013924108. Epub 2011 Mar 28.
5
Donor cell leukemia: a review.供者细胞白血病：综述。
Biol Blood Marrow Transplant. 2011 Jun;17(6):771-89. doi: 10.1016/j.bbmt.2010.10.010. Epub 2010 Oct 15.
6
Long-term cancer risk of immunosuppressive regimens after kidney transplantation.肾移植后免疫抑制方案的长期癌症风险。
J Am Soc Nephrol. 2010 May;21(5):852-8. doi: 10.1681/ASN.2009101043. Epub 2010 Apr 29.
7
Organ transplant recipients and skin cancer: assessment of risk factors with focus on sun exposure.器官移植受者与皮肤癌：危险因素评估，重点关注日照暴露。
Br J Dermatol. 2009 Nov;161 Suppl 3:85-9. doi: 10.1111/j.1365-2133.2009.09454.x.
8
Cancer incidence and risk factors after solid organ transplantation.实体器官移植后的癌症发病率及危险因素
Int J Cancer. 2009 Oct 15;125(8):1747-54. doi: 10.1002/ijc.24439.
9
Cancer screening in renal transplant recipients: what is the evidence?肾移植受者的癌症筛查：证据是什么？
Clin J Am Soc Nephrol. 2008 Mar;3 Suppl 2(Suppl 2):S87-S100. doi: 10.2215/CJN.03320807.
10
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.一种用于皮肤癌的诱导性小鼠模型揭示了功能获得性和功能丧失性p53突变的不同作用。
J Clin Invest. 2007 Jul;117(7):1893-901. doi: 10.1172/JCI31721.
Zotero 插件