Trissel Lawrence A, Saenz Christopher A, Ingram Delshalonda S, Williams Kimberly Y, Retzinger Julie P
Division of Pharmacy, The University of Texas, M.D. Anderson Cancer Center, Houston, Tx.
Int J Pharm Compd. 2002 May-Jun;6(3):230-3.
The physical compatibility of Precedex with 95 other drugs during simulated Y-site injection was evaluated by visual observation, turbidity measurement, and electronic particle content assessment (when appropriate). Five-milliliter samples of Precedex 4 micrograms/mL in 0.9% sodium chloride injection were combined with 5 mL of each of 95 other drugs. The other test drugs included anti-infectives, analgesics, antihistamines, diuretics, steroids, and other supportive-care drugs undiluted or diluted in 0.9% sodium chloride injection or 5% dextrose injection (for amphotericin B). Visual examinations were performed with the unaided eye in normal diffuse fluorescent light and with a Tyndall beam (a high-intensity monodirectional light beam) to enhance the visualization of small particles and low-level turbidity. The turbidity of each sample was measured as well, as was the particle content of samples with no visible incompatibility. Evaluation of the samples was performed initially and at 1 and 4 hours after preparation. Ninety-three of the 95 test drugs were compatible with the Precedex dilution during the 4-hour observation period; however, both amphotericin B and diazepam resulted in precipitation. Precedex, which is incompatible, with amphotericin B and diazepam, should not be administered simultaneously with those drugs.
通过视觉观察、浊度测量以及电子颗粒含量评估（如适用），对在模拟Y型接口注射过程中Precedex与其他95种药物的物理相容性进行了评估。将4微克/毫升Precedex的5毫升0.9%氯化钠注射液样本与95种其他药物中的每一种5毫升进行混合。其他受试药物包括未稀释或在0.9%氯化钠注射液或5%葡萄糖注射液（用于两性霉素B）中稀释的抗感染药、镇痛药、抗组胺药、利尿剂、类固醇以及其他支持性护理药物。视觉检查在正常漫射荧光灯下肉眼进行，并使用廷德尔光束（高强度单向光束）以增强对小颗粒和低水平浑浊度的可视化。还测量了每个样本的浊度，以及无明显不相容性样本的颗粒含量。在制备后最初以及1小时和4小时对样本进行评估。在4小时观察期内，95种受试药物中的93种与Precedex稀释液相容；然而，两性霉素B和地西泮均导致沉淀。与两性霉素B和地西泮不相容的Precedex不应与这些药物同时给药。
