通过一种中间 DNA 构象，由精脒卟啉缀合物诱导的(dA-T)(n) 双链体的 B-Z 转变。

B-Z transition of (dA-T)(n) duplexes induced by a spermine porphyrin-conjugate via an intermediate DNA conformation.

机构信息

Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

Chem Commun (Camb). 2013 Oct 11;49(79):9024-6. doi: 10.1039/c3cc45213a.

Abstract

The spermine conjugate of the cationic porphyrin ligand (1) selectively induced the B-Z transition of the [(dA-T)n]2 sequence at low salt concentrations. The [(dG-C)n]2 sequence was not transformed into the Z-form. The B-Z transition was induced via an intermediate DNA conformation, which was formed by the external binding and formation of an assembly of 1 onto B-DNA.

摘要

缩醛胺修饰的阳离子卟啉配体（1）能够在低盐浓度下选择性诱导 [(dA-T)n]2 序列发生 B-Z 转变，而 [(dG-C)n]2 序列则不能转化为 Z 型构象。B-Z 转变是通过一种中间的 DNA 构象诱导的，该构象是由 1 通过外部结合形成的组装体与 B-DNA 形成的。