State Key Laboratory of Bioreactor Engineering & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China.
Chem Soc Rev. 2014 Jan 7;43(1):30-41. doi: 10.1039/c3cs60174a. Epub 2013 Aug 27.
Quinones/hydroquinones (Q/HQ) are a class of prototypical redox molecules that play a variety of vital roles in biology, particularly in electron transfer and energy conservation systems. Biointerfaces supported on solid substrates or nanomaterials are widely used as biomimetic platforms that connect biological materials with artificial interfaces. Q/HQ-functionalized biointerfaces provide a new means for understanding the complex behaviors of Q/HQ at the interfaces of biological systems, and for further development of novel biomaterials and biosensors. This tutorial review provides a brief introduction to the recent advances in this field. We begin with the current methods used to functionalize Q/HQ on biointerfaces from the macro- to nano-scale (both solid substrates and nanomaterials), and then discuss their wide biological applications. Particularly exciting applications arise when Q/HQ-functionalized biointerface systems are coupled with biomimetic strategies. These systems can be used as models of other functionalized biointerfaces for biological applications, providing new insights into the future development of this area.
醌/氢醌（Q/HQ）是一类典型的氧化还原分子，在生物学中扮演着多种重要的角色，特别是在电子转移和能量守恒系统中。基于固体基底或纳米材料的生物界面被广泛用作连接生物材料与人工界面的仿生平台。Q/HQ 功能化的生物界面为理解 Q/HQ 在生物系统界面的复杂行为提供了一种新的手段，也为新型生物材料和生物传感器的进一步发展提供了可能。本综述教程简要介绍了该领域的最新进展。我们首先介绍了从宏观到纳米尺度（包括固体基底和纳米材料）上对 Q/HQ 进行功能化的现有方法，然后讨论了它们广泛的生物学应用。当 Q/HQ 功能化的生物界面系统与仿生策略结合使用时，特别令人兴奋的应用就会出现。这些系统可以作为其他功能化生物界面的模型，为该领域的未来发展提供新的见解。
