Jordon R E, Rapini R P, Rex I H, Katz H I, Hickman J G, Bard J W, Medansky R S, Lew-Kaya D A, Sefton J, DeGryse R E
Department of Medicine, University of Texas Health Science Center, Houston.
Int J Dermatol. 1990 Jul-Aug;29(6):441-2. doi: 10.1111/j.1365-4362.1990.tb03835.x.
Seventy patients with tinea cruris or tinea corporis were treated with naftifine cream 1% or vehicle once daily for 4 weeks in this double-blind, randomized study. After two weeks, the patients using naftifine had a significantly higher mycologic cure rate than the vehicle-treated patients (79% vs. 31%, p less than 0.001), and they showed significantly better resolution of signs and symptoms. Statistically significantly differences favoring naftifine over its vehicle were found throughout the treatment period and 2 weeks posttreatment.
在这项双盲、随机研究中，70例股癣或体癣患者每日一次外用1%萘替芬乳膏或赋形剂，持续4周。两周后，使用萘替芬的患者真菌学治愈率显著高于使用赋形剂的患者（79%对31%，p<0.001），且体征和症状的缓解情况明显更好。在整个治疗期间及治疗后2周，均发现萘替芬相对于其赋形剂有统计学显著差异。
