Sato Ken-ichi, Akai Shoji, Yoshimura Juji
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1, Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
Nat Prod Commun. 2013 Jul;8(7):987-98.
This report describes the stereocontrolled total synthesis of the multi-functionalized cyclitol derivative, tetrodotoxin, containing eight asymmetric carbons and different types of branched-chains, from myo-inositol and D-glucose using three different methods. The tetrodotoxin derivatives possess a relatively small molecular weight but unique structural and chemical properties. Selection of the appropriate synthetic method may be useful not only for compounds related to TTX (including related derivatives), but also for other highly complex multi-functionalized cyclitols containing branched-chains.
本报告描述了使用三种不同方法，从肌醇和D -葡萄糖出发，立体控制全合成多功能环糖醇衍生物河豚毒素的过程。河豚毒素含有八个不对称碳原子和不同类型的支链。河豚毒素衍生物分子量相对较小，但具有独特的结构和化学性质。选择合适的合成方法不仅对与TTX相关的化合物（包括相关衍生物）有用，而且对其他含有支链的高度复杂的多功能环糖醇也有用。
