Immunology Department, Faculty of Medicine, University of Porto, Porto, Portugal.
Pediatr Allergy Immunol. 2013 Sep;24(6):603-13. doi: 10.1111/pai.12111.
Atopic dermatitis (AD) is a relapsing inflammatory skin disease with a considerable social and economic burden. Functional textiles may have antimicrobial and antipruritic properties and have been used as complementary treatment in AD. We aimed to assess their effectiveness and safety in this setting. We carried out a systematic review of three large biomedical databases. GRADE approach was used to rate the levels of evidence and grade of recommendation. Meta-analyses of comparable studies were carried out. Thirteen studies (eight randomized controlled trials and five observational studies) met the eligibility criteria. Interventions were limited to silk (six studies), silver-coated cotton (five studies), borage oil, and ethylene vinyl alcohol (EVOH) fiber (one study each). Silver textiles were associated with improvement in SCORAD (2 of 4), fewer symptoms, a lower need for rescue medication (1 of 2), no difference in quality of life, decreased Staphyloccosus aureus colonization (2 of 3), and improvement of trans-epidermal water loss (1 of 2), with no safety concerns. Silk textile use was associated with improvement in SCORAD and symptoms (2 of 4), with no differences in quality of life or need for rescue medication. With borage oil use only skin erythema showed improvement, and with EVOH fiber, an improvement in eczema severity was reported. Recommendation for the use of functional textiles in AD treatment is weak, supported by low quality of evidence regarding effectiveness in AD symptoms and severity, with no evidence of hazardous consequences with their use. More studies with better methodology and longer follow-up are needed.
特应性皮炎（AD）是一种反复发作的炎症性皮肤病，具有相当大的社会和经济负担。功能性纺织品可能具有抗菌和止痒特性，并已被用作 AD 的辅助治疗。我们旨在评估其在这种情况下的有效性和安全性。我们对三个大型生物医学数据库进行了系统评价。使用 GRADE 方法对证据水平和推荐等级进行评级。对可比研究进行了荟萃分析。十三项研究（八项随机对照试验和五项观察性研究）符合入选标准。干预措施仅限于丝绸（六项研究）、镀银棉（五项研究）、琉璃苣油和乙烯-乙烯醇（EVOH）纤维（各一项研究）。银纺织品与 SCORAD 改善相关（4 项中有 2 项）、症状减少、对救援药物的需求降低（2 项中有 1 项）、生活质量无差异、金黄色葡萄球菌定植减少（3 项中有 2 项）以及经表皮水分流失改善（2 项中有 1 项），无安全性问题。丝绸纺织品的使用与 SCORAD 和症状改善相关（4 项中有 2 项），生活质量或对救援药物的需求无差异。只有使用琉璃苣油时皮肤红斑改善，而使用 EVOH 纤维时报告湿疹严重程度改善。弱推荐功能性纺织品用于 AD 治疗，其有效性和严重程度的证据质量低，使用它们没有危险后果的证据。需要更多具有更好方法学和更长随访时间的研究。
