Cardiology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Curr Atheroscler Rep. 2013 Oct;15(10):359. doi: 10.1007/s11883-013-0359-z.
Atherosclerosis imaging strategies can delineate characteristics of plaques at risk of rupture and thrombosis. Structural plaque imaging identifies high-risk plaque features, including lipid pools, thin fibrous caps, and intraplaque hemorrhage. New molecular imaging techniques complement structural imaging approaches by illuminating important features of plaque biology, with a prominent focus on detecting inflammation as a high-risk phenotype. As we unravel the molecular and structural characteristics underlying thrombosis-prone plaques, there is significant promise for eventual early identification and prediction of atherosclerotic plaque complications before they occur. Here we focus on recent imaging insights into high-risk arterial plaques, the etiologic agent of acute myocardial infarction, stroke, and sudden cardiac death.
动脉粥样硬化成像策略可以描绘易破裂和易血栓形成的斑块特征。结构斑块成像可识别高危斑块特征，包括脂质池、薄纤维帽和斑块内出血。新型分子成像技术通过阐明斑块生物学的重要特征来补充结构成像方法，其中突出强调了检测炎症作为一种高危表型。随着我们对易形成血栓的斑块的分子和结构特征的深入了解，最终有望在动脉粥样硬化斑块并发症发生之前，对其进行早期识别和预测。在这里，我们重点关注急性心肌梗死、中风和心源性猝死的病因——高危动脉斑块的最新成像研究进展。
