Dadds Mark R, Moul Caroline, Cauchi Avril, Hawes David J, Brennan John
aSchool of Psychology, University of New South Wales bSchool of Psychology, University of Sydney cChild and Adolescent Psychiatry, Sydney Children's Hospital, Sydney, New South Wales, Australia.
Psychiatr Genet. 2013 Dec;23(6):251-4. doi: 10.1097/YPG.0b013e3283650f83.
The co-occurrence of conduct problems (CPs) and high callous-unemotional (CU) traits specifies risk for adult psychopathy and is under a high genetic influence. A previous genome-wide pooled DNA study of 7-year olds identified a set of candidate single-nucleotide polymorphisms (SNPs) that might differentiate high CP+CU children from healthy children. We attempted to replicate an identified subset of these SNP-psychopathy associations. In a case-control design, 210 clinically referred children were partitioned into Comparison, High CP+Low CU, and High CP+CU groups and genotyped. One SNP, rs13064369, differentiated the groups but was associated with high CP, regardless of the level of CU traits, that is, the rare and heterozygote variants CC and CT were significantly more frequent in both CP groups compared with Comparisons but did not differ from each other. We replicated the finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy.
品行问题（CPs）与高冷酷无情（CU）特质同时出现表明存在成年期患精神病态的风险，且受高度遗传影响。之前一项针对7岁儿童的全基因组混合DNA研究确定了一组候选单核苷酸多态性（SNP），这些SNP可能会将高CP+CU儿童与健康儿童区分开来。我们试图重复这些SNP与精神病态关联中的一个已确定子集。在一项病例对照设计中，将210名临床转诊儿童分为对照组、高CP+低CU组和高CP+CU组，并进行基因分型。一个SNP，即rs13064369，能够区分这些组，但与高CP相关，无论CU特质水平如何，也就是说，罕见和杂合子变体CC和CT在两个CP组中均显著比对照组更常见，但两组之间没有差异。我们重复了这一发现，即与参与神经发育的ROBO2基因相关的一种多态性会带来品行障碍常见的情绪反应性、冲动性方面的风险，而与同时存在的精神病态风险无关。
