Colucci D'Amato C, Colucci D'Amato A, Alfano V, Giordano E, Marmo E
Department of Neurologic Sciences, First School of Medicine, University of Naples, Italy.
J Med. 1990;21(3-4):201-7.
The aim of our study was to evaluate the efficacy of long-term migraine prophylaxis with flunarizine. The efficacy of the drug was evaluated on the basis of the frequency, pain severity and duration of migraine attacks. Frequency, the most modified parameter, was reduced to about half of the pre-treatment level in one to three months time. The condition remained more or less stable from the third treatment month onwards. The results showed remarkable efficacy of long-term prophylaxis with flunarizine, and the response was better in younger patients with a short history of migraine.
我们研究的目的是评估氟桂利嗪长期预防偏头痛的疗效。基于偏头痛发作的频率、疼痛严重程度和持续时间对该药物的疗效进行评估。频率是变化最大的参数，在1至3个月的时间内降至治疗前水平的约一半。从第三个治疗月起病情或多或少保持稳定。结果表明氟桂利嗪长期预防效果显著，且偏头痛病史短的年轻患者反应更佳。
