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全身照射后发生急性横贯性脊髓炎:1例罕见病例。

An acute transverse myelitis attack after total body irradiation: a rare case.

作者信息

Keklik Muzaffer, Kaynar Leylagul, Yildirim Afra, Sivgin Serdar, Eroglu Celalettin, Cingoz Serife, Pala Cigdem, Eser Bulent, Cetin Mustafa, Unal Ali

机构信息

Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey.

出版信息

Case Rep Hematol. 2013;2013:523901. doi: 10.1155/2013/523901. Epub 2013 Jul 24.

DOI:10.1155/2013/523901
PMID:23984124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3741696/
Abstract

Total body irradiation (TBI) combined with chemotherapy is widely used as a pretreatment regimen of bone marrow transplantation (BMT) in hematologic disorders. Late complications related to TBI as part of the conditioning regimen for hematopoietic stem cell transplantation have been revealed. Acute transverse myelitis (ATM) is a neurological syndrome characterized by disorder of motor, sensorial, and autonomic nerves, and tracts at medulla spinalis, which is resulted from involvement of spinal cord. In this paper, we presented an ATM attack developed after TBI in a patient with acute lymphoblastic leukemia (ALL) as it is a rarely seen case.

摘要

全身照射(TBI)联合化疗被广泛用作血液系统疾病骨髓移植(BMT)的预处理方案。作为造血干细胞移植预处理方案一部分的TBI相关晚期并发症已被揭示。急性横贯性脊髓炎(ATM)是一种神经综合征,其特征是运动、感觉和自主神经以及脊髓髓质的传导束出现紊乱,这是由脊髓受累引起的。在本文中,我们报告了1例急性淋巴细胞白血病(ALL)患者在TBI后发生ATM发作的病例,因为这是1例罕见病例。

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引用本文的文献

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Clin Hematol Int. 2019 Mar 18;1(1):19-27. doi: 10.2991/chi.d.190218.002. eCollection 2019 Mar.
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Ann Med Surg (Lond). 2021 Aug 18;69:102728. doi: 10.1016/j.amsu.2021.102728. eCollection 2021 Sep.
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[Paraplegia after hematopoietic stem cell transplantation].

本文引用的文献

1
Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia.全身照射、环磷酰胺和阿糖胞苷作为急性淋巴细胞白血病患者异基因造血干细胞移植预处理方案的安全性和有效性。
Am J Hematol. 2012 Apr;87(4):349-53. doi: 10.1002/ajh.23109. Epub 2012 Jan 31.
2
Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation.全身照射后行干细胞移植并发干骺端异常的骨软骨瘤。
J Pediatr Hematol Oncol. 2012 Jul;34(5):378-82. doi: 10.1097/MPH.0b013e3182332296.
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Comparison of total body irradiation before and after chemotherapy in pretreatment for hematopoietic stem cell transplantation.
预处理造血干细胞移植中化疗前后全身照射的比较。
Cancer Biother Radiopharm. 2012 Mar;27(2):119-23. doi: 10.1089/cbr.2011.1041. Epub 2011 Dec 8.
4
Cyclophosphamide plus total body irradiation compared with busulfan plus cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplantation in patients with leukemia: a systematic review and meta-analysis.白血病患者造血干细胞移植前,环磷酰胺加全身照射与白消安加环磷酰胺作为预处理方案的比较:一项系统评价和荟萃分析。
Hematol Oncol Stem Cell Ther. 2011;4(1):17-29. doi: 10.5144/1658-3876.2011.17.
5
Late toxicity in children undergoing hematopoietic stem cell transplantation with TBI-containing conditioning regimens for hematological malignancies.接受含全身照射预处理方案的造血干细胞移植治疗血液系统恶性肿瘤的儿童的晚期毒性反应。
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6
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