Hagan M E, Holland C S, Herrick C M, Rasmussen L G
Utah Transplantation Affiliated Hospitals, Cardiac Transplant Program, University of Utah Medical Center, Salt Lake City.
J Heart Transplant. 1990 Jul-Aug;9(4):382-4.
After heart transplantation, recipients frequently become obese. Although the cause is undoubtedly multifactorial, administration of corticosteroids may contribute to posttransplant obesity. To test this hypothesis, we retrospectively reviewed the change in body weight with respect to corticosteroid use after transplantation in all 110 recipients surviving 1 year in the UTAH Cardiac Transplant Program. Fifty-two recipients (47%, group 1) were unable to be withdrawn from maintenance corticosteroids, and 58 recipients (53%, group 2) were successfully withdrawn, the latter group requiring only cyclosporine and azathioprine long-term maintenance immunosuppression. The change in weight from the time of transplantation to 1 year after transplantation in group 1 was 8.7 +/- 1.1 kg; group 2 patients gained only 4.9 +/- 0.9 kg (p = 0.009). In conclusion, successful withdrawal of maintenance corticosteroids after heart transplantation decreased posttransplant weight gain, suggesting that posttransplant obesity is in part related to use of corticosteroids.
心脏移植后，受者常常会出现肥胖。尽管其原因无疑是多因素的，但使用皮质类固醇可能导致移植后肥胖。为验证这一假设，我们回顾性分析了犹他心脏移植项目中存活1年的110例受者移植后使用皮质类固醇与体重变化的关系。52例受者（47%，第1组）无法停用维持剂量的皮质类固醇，58例受者（53%，第2组）成功停用，后一组仅需长期使用环孢素和硫唑嘌呤进行维持性免疫抑制。第1组从移植时到移植后1年体重增加8.7±1.1千克；第2组患者仅增加4.9±0.9千克（p = 0.009）。总之，心脏移植后成功停用维持剂量的皮质类固醇可减少移植后体重增加，提示移植后肥胖部分与皮质类固醇的使用有关。
