在艾伯塔省的一个样本中，汞合金牙面与尿汞水平之间的关联，一项流行性病学研究。
The association between amalgam dental surfaces and urinary mercury levels in a sample of Albertans, a prevalence study.
机构信息
Department of Community Health Sciences, University of Calgary, 3rd Floor, TRW Building, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.
出版信息
J Occup Med Toxicol. 2013 Aug 29;8(1):22. doi: 10.1186/1745-6673-8-22.
OBJECTIVE
The objective of this study was to quantify the relationship between number of dental amalgam surfaces and urinary mercury levels.
METHODS
This study uses participant data from a large philanthropic chronic disease prevention program in Calgary, Alberta, Canada. Urine samples were analysed for mercury levels (measured in μg/g-creatinine). T-tests were used to determine if differences in urine mercury were statistically significant between persons with no dental amalgam surfaces and one or more dental amalgam surfaces. Linear regression was used to estimate the change in urinary mercury per amalgam surface.
RESULTS
Urinary mercury levels were statistically significantly higher in participants with amalgam surfaces, with an average difference of 0.55 μg/g-creatinine. Per amalgam surface, we estimated an expected increase of 0.04 μg/g-creatinine. Measured urinary mercury levels were also statistically significantly higher in participants with dental amalgam surfaces following the oral administration of 2,3-dimercaptopropane-l-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) which are used to mobilize mercury from the blood and tissues.
DISCUSSION
Our estimates indicate that an individual with seven or more dental amalgam surfaces has 30% to 50% higher urinary mercury levels than an individual without amalgams. This is consistent with past literature that has identified seven amalgam surfaces as an unsafe level of exposure to mercury vapor. Our analysis suggests that continued use of silver amalgam dental fillings for restorative dentistry is a non-negligible, unnecessary source of mercury exposure considering the availability of composite resin alternatives.
目的
本研究旨在量化牙齿汞合金表面数量与尿汞水平之间的关系。
方法
本研究使用了来自加拿大阿尔伯塔省卡尔加里市一项大型慈善慢性病预防计划的参与者数据。对尿液样本进行汞水平分析（以μg/g-肌酐表示）。使用 t 检验确定无汞合金表面和一个或多个汞合金表面的个体之间尿汞是否存在统计学差异。线性回归用于估计每个汞合金表面尿液汞的变化。
结果
有汞合金表面的参与者尿液汞水平显著升高，平均差异为 0.55μg/g-肌酐。每颗汞合金，我们估计预期会增加 0.04μg/g-肌酐。在参与者口服 2,3-二巯基丙磺酸钠（DMPS）和内消旋-2,3-二巯基丁二酸（DMSA）后，测量的尿液汞水平也有统计学显著升高，这两种药物用于从血液和组织中动员汞。
讨论
我们的估计表明，有 7 颗或更多牙齿汞合金的个体的尿汞水平比没有汞合金的个体高 30%至 50%。这与过去的文献一致，该文献已确定 7 颗汞合金表面是暴露于汞蒸气的不安全水平。我们的分析表明，考虑到复合树脂替代品的可用性，继续将银汞合金牙填充物用于修复牙科是一种不可忽视的、不必要的汞暴露源。
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