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尿流率对儿童体内汞排泄的影响。

The influence of urinary flow rate on mercury excretion in children.

机构信息

New England Research Institutes, Watertown, MA 02472, USA.

出版信息

J Trace Elem Med Biol. 2010 Jan;24(1):31-5. doi: 10.1016/j.jtemb.2009.06.003. Epub 2009 Aug 5.

DOI:10.1016/j.jtemb.2009.06.003
PMID:20122577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2818046/
Abstract

PROJECT

There is limited literature concerning the effect of urinary flow rate on mercury excretion at low-level exposure. The aim of the present study is to examine the influence of urinary flow rate on mercury excretion in children. Also of interest is the influence of flow rate on creatinine excretion and creatinine-corrected mercury, which arisearises with spot urine samples.

PROCEDURE

A substudy of the New England Children's Amalgam Trial collected pairs of urine samples from children aged 10-16 years: a timed overnight collection and a spot daytime sample collected the following day. These samples were analyzed for mercury and creatinine concentration. Regression analysis was used to model the effect of urinary flow rate in the timed overnight samples. A paired t-test compared concentrations and creatinine-corrected mercury between overnight and daytime samples.

RESULTS

Creatinine excretion rate (mg/h) increased significantly with urinary flow rate (mL/h), whereas creatinine concentration (g/L) decreased with flow rate. We found a non-significant increase in mercury excretion rate (ng/h) with flow rate, and mercury concentration decreased with flow rate. Mercury and creatinine concentrations were significantly higher in the overnight compared to daytime samples. For creatinine-corrected mercury, no significant impact of urinary flow rate was found.

CONCLUSIONS

Although the creatinine excretion rate, and probably the mercury excretion rate, increased with urinary flow rate, the mercury/creatinine ratio seemed relatively unaffected by urinary flow rate.

摘要

项目

关于低水平暴露下尿流率对汞排泄影响的文献有限。本研究旨在探讨尿流率对儿童汞排泄的影响。同样有趣的是，尿流率对肌酐排泄和肌酐校正后的汞的影响，这在随机尿样中出现。

程序

新英格兰儿童汞合金试验的一项子研究从 10-16 岁的儿童中收集了一对尿液样本：一个定时的夜间采集和第二天白天的一个随机样本。这些样本用于分析汞和肌酐浓度。回归分析用于模拟定时夜间样本中尿流率的影响。配对 t 检验比较了夜间和白天样本的浓度和肌酐校正后的汞。

结果

肌酐排泄率（mg/h）随尿流率（mL/h）显著增加，而肌酐浓度（g/L）随尿流率降低。我们发现，尿流率与汞排泄率呈非显著增加趋势，而汞浓度随尿流率降低。与白天样本相比，夜间样本中的汞和肌酐浓度显著升高。对于肌酐校正后的汞，尿流率没有显著影响。

结论

尽管肌酐排泄率，可能还有汞排泄率随尿流率增加，但汞/肌酐比值似乎不受尿流率的影响。

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