H. Lee Moffitt Cancer Center and Research Institute, Department of Thoracic Oncology and Chemical Biology and Molecular Medicine Program , 12902 Magnolia Dr. Tampa, FL 33612 , USA
Expert Opin Ther Targets. 2013 Oct;17(10):1109-12. doi: 10.1517/14728222.2013.833188. Epub 2013 Aug 28.
It is well known that non-canonical IκB kinases (IKK), IKKϵ and Tank-binding kinase 1 (TBK1), play a key role in anti-viral responses. Interestingly, they have recently emerged as novel survival kinases in several human cancers including lung cancer, given their roles in maintaining cancer cell survival and promoting oncogenic transformation. However, the molecular mechanisms by which IKKϵ/TBK1 are activated and IKKϵ/TBK1 mediate survival signal in cancer cells are still controversial. This article will briefly describe signaling pathways mediated by these non-canonical IKKs, especially focusing in lung cancer, and discuss their potential as molecular targets for lung cancer treatment.
众所周知，非经典的 IκB 激酶（IKK）、IKKε 和 Tank 结合激酶 1（TBK1）在抗病毒反应中发挥关键作用。有趣的是，鉴于它们在维持癌细胞存活和促进致癌转化中的作用，它们最近已成为几种人类癌症（包括肺癌）中的新型存活激酶。然而，IKKε/TBK1 被激活的分子机制以及 IKKε/TBK1 在癌细胞中介导存活信号的分子机制仍存在争议。本文将简要描述这些非经典 IKK 介导的信号通路，特别是在肺癌中的作用，并讨论它们作为肺癌治疗的分子靶点的潜力。
