Huan Jing-ning
Department of Burns and Plastic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhonghua Shao Shang Za Zhi. 2013 Apr;29(2):144-7.
Fungal infection is one of the serious complications of severely burned patients with high mortality. Application of antifungal agents timely and rationally is very important to control the infection. Antifungal agents including polyenes,triazoles, and echinocandins have been used widely in burned patients and are proved to be effective. Since diagnosis of fungal infection remains difficult, prophylactic and empirical therapies appear to be particularly necessary. In order to improve the efficacy and safety of antifungal agents, the factors of fungal strains, infection sites, hepatic and renal functions, and age, etc. should be considered in selecting antifungal agents.
真菌感染是重度烧伤患者的严重并发症之一，死亡率很高。及时、合理应用抗真菌药物对于控制感染非常重要。包括多烯类、三唑类和棘白菌素类在内的抗真菌药物已在烧伤患者中广泛使用，并被证明是有效的。由于真菌感染的诊断仍然困难，预防性和经验性治疗似乎尤为必要。为了提高抗真菌药物的疗效和安全性，在选择抗真菌药物时应考虑真菌菌株、感染部位、肝肾功能和年龄等因素。
