Gao Yu-lei, Chai Yan-fen, Yao Yong-ming
Emergency Department of General Hospital, Tianjin Medical University, Tianjin 300052, China.
Zhonghua Shao Shang Za Zhi. 2013 Apr;29(2):162-5.
Sepsis is a systemic inflammatory response syndrome resulting from a host response to infection. The early stage of sepsis is characterized by excessive inflammatory response, accompanied by immune dysfunction characterized by aggravating cellular immunosuppression. The vast majority of patients with sepsis survive the initial excessive inflammatory response, but die of hospital-acquired infection, opportunistic pathogenic bacteria infection, latent virus reactivation, and multiple organ dysfunction syndrome. These facts indicate that immunosuppression may be a significant cause of exacerbation of the illness even death of the septic patients. The primary cellular mechanisms in inducing immune dysfunction include immune dysfunction of T lymphocytes, negative regulation of regulatory T lymphocytes and dendritic cells, and damage of intestinal mucosa associated lymphoid tissue. Xuebijing injection is a complex Chinese patent medicine, which is widely used in the treatment of sepsis. It has a potential immunoregulation ability, as well as effects on bacteriostasis, anti-endotoxin and anti-inflammation. Its target and mechanism of action need to be explored further.
脓毒症是宿主对感染的反应所导致的一种全身炎症反应综合征。脓毒症的早期特征为过度的炎症反应，并伴有以细胞免疫抑制加重为特征的免疫功能障碍。绝大多数脓毒症患者在最初的过度炎症反应中存活下来，但死于医院获得性感染、机会性病原菌感染、潜伏病毒再激活以及多器官功能障碍综合征。这些事实表明，免疫抑制可能是脓毒症患者病情加重甚至死亡的重要原因。诱导免疫功能障碍的主要细胞机制包括T淋巴细胞的免疫功能障碍、调节性T淋巴细胞和树突状细胞的负调控以及肠道黏膜相关淋巴组织的损伤。血必净注射液是一种复方中成药，广泛用于脓毒症的治疗。它具有潜在的免疫调节能力，以及抑菌、抗内毒素和抗炎作用。其作用靶点和机制有待进一步探索。
