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在人类免疫缺陷病毒1型负调控元件内鉴定顺式作用抑制序列。

Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1.

作者信息

Lu Y C, Touzjian N, Stenzel M, Dorfman T, Sodroski J G, Haseltine W A

机构信息

Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts.

出版信息

J Virol. 1990 Oct;64(10):5226-9. doi: 10.1128/JVI.64.10.5226-5229.1990.

DOI:10.1128/JVI.64.10.5226-5229.1990
PMID:2398545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248024/
Abstract

The negative regulatory element of human immunodeficiency virus type 1 is a 260-nucleotide-long sequence that decreases the rate of RNA transcription initiation specified by the long terminal repeat. This region has the potential to bind several cellular transcription factors. Here it is shown that sequences which recognize the NFAT-1 and USF cellular transcription factors contribute to this negative regulatory effect. The sequences within the negative regulatory element which resemble the AP-1 site and the URS do not negatively regulate human immunodeficiency virus long terminal repeat transcription initiation.

摘要

人类免疫缺陷病毒1型的负调控元件是一段260个核苷酸长的序列，它降低了由长末端重复序列指定的RNA转录起始速率。该区域有可能结合几种细胞转录因子。本文表明，识别NFAT-1和USF细胞转录因子的序列对这种负调控效应有贡献。负调控元件中类似于AP-1位点和URS的序列不会对人类免疫缺陷病毒长末端重复序列的转录起始产生负调控作用。