Solopov V N, Lunichkina I V
Klin Med (Mosk). 1990 May;68(5):60-5.
The paper is concerned with an analysis of the original data and the conception regarding the pathogenesis of expectoration alterations and correction in patients with chronic obstructive pulmonary diseases (COPD). Expectoration defects in COPD are suggested to be classified according to duration of respiratory tract clearing from sputum. The disorders of the first and second degree amenable to correction by oral and inhalation expectorants are referred to compensation stage, those of the third degree resistant to the correction to decompensation stage. Efficiency of current expectorants is comparatively assessed as well as mechanisms of their actions. An approach to expectorants administration should be differential basing on the severity of relevant impairment and aimed at adequate maintenance or recovery of the sputum discharge in COPD patients.
本文涉及对慢性阻塞性肺疾病(COPD)患者咳痰改变及纠正的发病机制的原始数据和概念分析。COPD患者的咳痰缺陷建议根据呼吸道清除痰液的持续时间进行分类。一、二级咳痰障碍可通过口服和吸入祛痰剂纠正,称为代偿期;三级咳痰障碍难以纠正,称为失代偿期。同时对现有祛痰剂的疗效及其作用机制进行了比较评估。祛痰剂的给药方法应根据相关损伤的严重程度进行区分,旨在使COPD患者的痰液排出得到充分维持或恢复。