Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.
Carbohydr Polym. 2013 Oct 15;98(1):1083-94. doi: 10.1016/j.carbpol.2013.07.037. Epub 2013 Jul 18.
Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), (13)C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M).
用硝酸铈铵作氧化还原引发剂，通过微波辐射制备了槐豆胶接枝共聚物。以固定量的天然槐豆胶为基准，通过控制辐射时间、引发剂用量和丙烯酰胺用量对接枝过程进行了优化。通过傅里叶变换红外光谱（FT-IR）、（13）C 核磁共振（NMR）、扫描电子显微镜（SEM）、X 射线衍射研究（XRD）、差示扫描量热法（DSC）、元素分析、接触角、粘度、分子量、溶胀和生物降解性研究对接枝胶进行了表征。接枝胶可生物降解且无毒性。进一步将其用于制备盐酸丁咯地尔的控制释放基质片剂。片剂的体外释放曲线表明，丙烯酰胺接枝槐豆胶的控释性能与羟丙基甲基纤维素（HPMC-K15M）相似。
