[青蒿素及其衍生物抗肿瘤活性的研究进展]

[Research advance in antitumor activities of artemisinin and its derivatives].

作者信息

Yang Hua, Tan Xian-jie

机构信息

Department of Obstetrics and Gynecology, PUMC Hospital, Beijing, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Aug;35(4):466-71. doi: 10.3881/j.issn.1000-503X.2013.04.021.

DOI:10.3881/j.issn.1000-503X.2013.04.021

PMID:23987499

Abstract

Artemisinin and its derivatives are highly effective in fighting against malaria. Notably, these drugs have shown potent anti-timor activities by arresting cellular growth, enhancing apoptosis, inhibiting angiogenesis, and regulating the expression of tumor-associated genes, although the underlying mechanisms remain unclear.

摘要

青蒿素及其衍生物在对抗疟疾方面非常有效。值得注意的是，这些药物通过阻止细胞生长、增强细胞凋亡、抑制血管生成以及调节肿瘤相关基因的表达，显示出强大的抗肿瘤活性，尽管其潜在机制仍不清楚。