Department of Pediatric Surgery, Izhevsk State Medical Academy, Kommunarov str., 281, Izhevsk, 426034, Russia.
Bosn J Basic Med Sci. 2013 Aug;13(3):153-7. doi: 10.17305/bjbms.2013.2348.
The goal of our work was to study the changes in the bone tissue, bone marrow and surrounding tissues in animals during early stages of experimental osteomyelitis. Osteomyelitis was simulated in 30 infants rabbits aged 3-4 months whose body weight accounted 1200-1600 grams through the insertion of 5-6 million of aurococcus into the marrow channel of a shinbone. The study of bone marrow, bone tissue and surrounding tissue was conducted 30 minutes, 6, 12, 24, 48 and 60 hours after the contamination with the help of light and electronic (transmission and scanning) microscopy. It was proved that the first changes are characterized by the evident changes in the vessel's walls which cause the swelling of bone marrow and suppurative inflammation in the bone tissue occurs only in the end of the 3d day of the experiment. These data confirm the necessity of osteoperfortation during the first 24 hours of contamination in order to remove the swelling and to correct vessel disorders.
我们工作的目的是研究实验性骨髓炎早期动物骨组织、骨髓和周围组织的变化。通过将 500 万至 600 万金黄色葡萄球菌注入胫骨骨髓腔，模拟了 30 只 3 至 4 月龄的婴儿兔的骨髓炎。在污染后 30 分钟、6、12、24、48 和 60 小时，借助光学显微镜和电子显微镜（透射和扫描）研究了骨髓、骨组织和周围组织。事实证明，最早的变化的特征是血管壁的明显变化，这导致骨髓肿胀，而骨组织中的化脓性炎症仅在实验的第 3 天结束时发生。这些数据证实，在污染后的头 24 小时内必须进行骨切开术，以消除肿胀并纠正血管紊乱。
