Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Ultrasound Med Biol. 2013 Nov;39(11):1966-75. doi: 10.1016/j.ultrasmedbio.2013.06.006. Epub 2013 Aug 26.
The objective of the study was to measure fetal aortic pulse wave velocity and lumen diameter waveforms and subsequently calculate local distensibility, compliance and pulse pressure. A dedicated algorithm for optimizing lumen diameter assessment from radiofrequency ultrasound data is described. Biplane raw data were obtained from a matrix array transducer. We evaluated 83 confirmed, normally developing pregnancies at 22-38 wk. Fetal aortic pulse wave velocity (PWV, m/s) = 0.047 × gestational age (wk) + 1.241, and the distensibility coefficient (1/kPa) = 1/(1.04 × PWV(2)). The logarithm of the local compliance index (mm(2)/kPa) and the pulse pressure (kPa) were both linearly related to gestational age as 0.022 × GA (wk) - 0.343 and 0.012 × GA (wk) + 0.931, respectively. In conclusion, fetal aortic elastic properties can be derived from phase-sensitive radiofrequency data and multiline diameter assessment. Future studies may shed further light on the developmental origins of vascular health and disease.
本研究旨在测量胎儿主动脉脉搏波速度和管腔直径波形，随后计算局部扩张性、顺应性和脉压。描述了一种用于从射频超声数据优化管腔直径评估的专用算法。双平面原始数据来自矩阵阵列换能器获得。我们评估了 83 例在 22-38 周确认的正常发育妊娠。胎儿主动脉脉搏波速度（PWV，m/s）= 0.047×孕周（wk）+1.241，可扩张系数（1/kPa）= 1/（1.04×PWV(2)）。局部顺应性指数（mm(2)/kPa）和脉压（kPa）的对数均与胎龄呈线性关系，分别为 0.022×GA（wk）-0.343 和 0.012×GA（wk）+0.931。总之，胎儿主动脉弹性特性可从相敏射频数据和多线直径评估中得出。未来的研究可能会进一步阐明血管健康和疾病的发育起源。
