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主动脉缩窄中的高血压:儿童诊断面临的挑战

Hypertension in Coarctation of the Aorta: Challenges in Diagnosis in Children.

作者信息

Vigneswaran Trisha V, Sinha Manish D, Valverde Israel, Simpson John M, Charakida Marietta

机构信息

Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's & St Thomas' Hospitals, London, SE1 7EH, UK.

Division of Imaging Sciences, Kings College London British Heart Foundation Centre, NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust, Westminster Bridge Rd, London, SE1 7EH, UK.

出版信息

Pediatr Cardiol. 2018 Jan;39(1):1-10. doi: 10.1007/s00246-017-1739-x. Epub 2017 Oct 17.

Abstract

Evidence indicates that patients with coarctation of the aorta (COA) suffer from increased cardiovascular morbidity and mortality in later life despite successful repair of COA in childhood. Systolic arterial hypertension is common, presenting in up to one-third of patients, and is regarded as the main driver of premature cardiovascular events in this group of patients. In this review, we discuss the prevalence and pathophysiology of hypertension in children following successful COA repair with no residual arch obstruction. The challenges in accurate blood pressure assessment at this early phase are considered and non-invasive measures of central blood pressure are discussed. Although the pathways for investigations in adults are well defined, we highlight the need to address the issues of cardiovascular surveillance in children and describe techniques which can provide complementary information for cardiovascular assessment in this group of patients such that timely treatment can occur.

摘要

有证据表明,尽管主动脉缩窄(COA)患者在儿童期已成功修复,但在晚年仍面临心血管发病率和死亡率增加的问题。收缩期动脉高血压很常见,在多达三分之一的患者中出现,被认为是该组患者心血管事件过早发生的主要驱动因素。在本综述中,我们讨论了成功修复COA且无残余弓部梗阻的儿童高血压的患病率和病理生理学。考虑了在此早期阶段准确血压评估的挑战,并讨论了中心血压的非侵入性测量方法。尽管成人的检查途径已明确,但我们强调需要解决儿童心血管监测问题,并描述可为该组患者心血管评估提供补充信息的技术,以便能够及时进行治疗。

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