Dinh Xuan A T
Laboratoire d'Explorations Fonctionnelles, Hospital Cochin, Paris, France.
Med Hypotheses. 1990 Jul;32(3):207-9. doi: 10.1016/0306-9877(90)90124-w.
Bronchial smooth muscle contraction is not the only causative factor of airway narrowing in asthma. Other components, such as mucosal and submucosal oedema and mucosal inflammation, also intervene in the processes leading to bronchial obstruction. Re-analyzing the role of the tracheo-bronchial circulation is therefore necessary, since participation of the latter, through modification of bronchial blood flow and/or alteration of microvascular permeability, very likely modifies mucosal thickness of the bronchial wall and/or clearance of bronchoactive substances from the airways. This also implies that more attention should be paid on the vascular actions of compounds which are either currently prescribed or under development for future treatment of asthma.
支气管平滑肌收缩并非哮喘气道狭窄的唯一致病因素。其他因素，如黏膜和黏膜下水肿以及黏膜炎症，也参与导致支气管阻塞的过程。因此，重新分析气管 - 支气管循环的作用很有必要，因为后者通过改变支气管血流和/或改变微血管通透性，很可能会改变支气管壁的黏膜厚度和/或气道中支气管活性物质的清除。这也意味着应更加关注目前正在使用或正在研发用于未来哮喘治疗的化合物的血管作用。
