German Center for Vertigo and Balance Disorders, University of Munich, Grosshadern Medical Center, Marchioninistr, Munich, Germany.
Otol Neurotol. 2014 Feb;35(2):289-93. doi: 10.1097/MAO.0b013e318299a812.
Ocular vestibular evoked myogenic potentials (oVEMP) represent extraocular muscle activity in response to vestibular stimulation. oVEMP amplitudes are known to be modulated by gaze elevation. However, it is not well known to which extent oVEMP are modulated by upward gaze. We thus investigated the effects of commonly used upward gaze angles on oVEMP amplitudes and latencies.
Prospective study.
Tertiary referral center for vestibular disorders.
Thirty-two healthy subjects were enrolled in this study.
500 Hz air-conducted tone bursts were used to elicit oVEMP with the subject maintaining 30 and 35 degrees and maximal upward gaze, respectively.
Amplitudes and latencies of oVEMP responses.
n1-p1 amplitudes significantly increased with increasing gaze angle from 30 to 35 degrees. Maximal up-gaze, however, did not result in further enlargement of amplitudes. Latencies were not affected by gaze elevation.
A small increase in upward gaze angle caused a considerable augmentation of amplitudes. Controlling the level of gaze when recording oVEMP is thus indispensable to ensure interindividual and intraindividual comparability of oVEMP results.
眼性前庭诱发肌源性电位（oVEMP）代表了前庭刺激时眼外肌的活动。oVEMP 幅度已知会受到注视抬高的调节。然而，oVEMP 受向上注视调节的程度尚不清楚。因此，我们研究了常用的向上注视角度对视神经诱发电位幅度和潜伏期的影响。
前瞻性研究。
前庭疾病的三级转诊中心。
32 名健康受试者纳入本研究。
使用 500Hz 空气传导声刺激诱发 oVEMP，受试者分别保持 30 度和 35 度最大向上注视。
oVEMP 反应的幅度和潜伏期。
n1-p1 幅度随着注视角度从 30 度增加到 35 度而显著增加。然而，最大上视并没有进一步增大幅度。潜伏期不受注视抬高的影响。
向上注视角度的小幅度增加会导致幅度的显著增加。因此，在记录 oVEMP 时控制注视水平对于确保 oVEMP 结果在个体间和个体内的可比性是不可或缺的。
