Department of Biochemistry, Tokyo Medical University, 6-1-1 Shinjuku, Tokyo 160-8402, Japan.
Int J Mol Sci. 2013 Aug 28;14(9):17573-83. doi: 10.3390/ijms140917573.
2-Aminophenoxazine-3-one (Phx-3), an oxidative phenoxazine, exerts strong anticancer effects on various cancer cell lines originating from different organs, in vitro. This article reviews new aspects for the prevention of carcinogenesis and development of gastric and colon cancers by Phx-3, based on the strong anticancer effects of Phx-3 on gastric and colon cancer cell lines (direct anticancer effects of Phx-3 for preventing development of cancer), the bacteriocidal effects of Phx-3 against Helicobacter pylori associated with carcinogenesis of gastric cancer (indirect anticancer effects for preventing carcinogenesis of gastric cancer), and the proapoptotic activity of Phx-3 against human neutrophils involved in the incidence of ulcerative colitis associated with a high colon cancer risk (indirect anticancer effects for preventing carcinogenesis of colon cancer).
2-氨基吩嗪-3-酮（Phx-3）是一种氧化吩嗪，在体外对来自不同器官的各种癌细胞系具有强烈的抗癌作用。本文综述了 Phx-3 通过以下几个方面在预防胃癌和结肠癌发生和发展方面的新作用：Phx-3 对胃癌和结肠癌细胞系的强烈抗癌作用（Phx-3 的直接抗癌作用可预防癌症的发生）、Phx-3 对与胃癌发生相关的幽门螺杆菌的杀菌作用（预防胃癌发生的间接抗癌作用）以及 Phx-3 对参与溃疡性结肠炎发生的人中性粒细胞的促凋亡活性（预防结肠癌发生的间接抗癌作用，结肠癌风险较高）。
