Moreno-Moraga Javier, Smarandache Adriana, Pascu Mihail L, Royo Josefina, Trelles Mario A
Instituto Médico Láser, Madrid, Spain.
National Institute for Laser, Plasma and Radiation Physics, Bucharest, Romania.
Phlebology. 2014 Dec;29(10):658-66. doi: 10.1177/0268355513502786. Epub 2013 Aug 29.
To assess the efficacy and safety of a new method of clearing varicose veins in the long term. It consists of applying the long-pulsed Nd:YAG laser following the injection of polidocanol microfoam, in two consecutive sessions, treating both legs in full in each session.
Randomized, Polidocanol-controlled, blind evaluation clinical trial comparing the results between 79 legs treated with Polidocanol and 517 treated with Polidocanol + Laser. Photographs were taken preoperatively and at three months, two years and three years after treatment, as well as patient self-assessments.
Polidocanol + Laser is much more effective than polidocanol microfoam in clearing venulectasias with a diameter under 4 mm (p < 0.001). After three years, clearing percentages of 89% (Class I veins), 94% (Class II veins) and 95% (Class III veins) are observed, in comparison to 15%, 18% and 17%, respectively when only polidocanol was applied. No unexpected adverse effects were found and 86% of patients stated they were Satisfied or Very Satisfied.
The method leads to safe, fast and apparently permanent results. The treatment session lasts less than 1 h, and could become a first-choice treatment for the removal of all types of varicose veins with a diameter under 4 mm.
长期评估一种治疗静脉曲张新方法的疗效和安全性。该方法是在注射聚多卡醇微泡沫后应用长脉冲Nd:YAG激光，分两个连续疗程进行，每个疗程对双腿进行全面治疗。
随机、聚多卡醇对照、盲法评估的临床试验，比较79条接受聚多卡醇治疗的腿和517条接受聚多卡醇+激光治疗的腿的结果。在术前、治疗后3个月、2年和3年拍摄照片，并进行患者自我评估。
在清除直径小于4mm的静脉扩张方面，聚多卡醇+激光比聚多卡醇微泡沫有效得多（p<0.001）。三年后，观察到I级静脉清除率为89%，II级静脉为94%，III级静脉为95%，而仅应用聚多卡醇时分别为15%、18%和17%。未发现意外不良反应，86%的患者表示满意或非常满意。
该方法能带来安全、快速且明显持久的效果。治疗疗程持续时间不到1小时，可成为清除所有直径小于4mm的各类静脉曲张的首选治疗方法。
