Lowery J A, Parel J M, Roussel T J, Simon G, Lee W, Nose I
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33101.
Ophthalmic Surg. 1990 Jul;21(7):522-8.
A portable system for holding, accurately positioning, and restoring the physiologic integrity of enucleated globes during experimental anterior segment procedures and pars plana vitrectomy is described. A 0 to 500-mm Hg vacuum fixation ring and positioning apparatus mechanically locks globes into known spatial position while they are supported in a 2 to 6-mm Hg pressurized, pliable socket designed to match the size and pressure of a natural orbit. A gravity infusion system and an implantable piezoelectric pressure sensor in conjunction with a syringe and stopcock assembly allow for controlled inflation of globes to intraocular pressure (IOP) levels from 0 to 70 mm Hg, and to over 300 mm Hg. The fixation vacuum level, and intraocular and extraocular pressures are simultaneously monitored on 3-digit LED displays, and permanent records of each can be generated by routing data to storage devices. The anterior segment remains accessible at all times for surgical procedures and diagnostic measurements. The entire system is portable, allowing globes to be transported to multiple experimental stations, while all pressure settings and the position of the globe are maintained. To demonstrate applications of the artificial orbit system, we describe experiments using it to calibrate applanation tonometers, and to study the relationship between IOP and corneal curvature as well as the effect of trephination procedures and limbal vacuum fixation on IOP.
本文描述了一种便携式系统，用于在实验性眼前节手术和玻璃体切割术中固定、精确放置并恢复摘除眼球的生理完整性。一个0至500毫米汞柱的真空固定环和定位装置可将眼球机械锁定在已知空间位置，此时眼球被支撑在一个2至6毫米汞柱压力的柔韧眼窝中，该眼窝的大小和压力设计为与自然眼眶相匹配。重力输液系统和植入式压电压力传感器与注射器和旋塞组件配合，可将眼球控制充气至0至70毫米汞柱的眼内压（IOP）水平，并可超过300毫米汞柱。固定真空度、眼内压和眼外压在三位LED显示屏上同时监测，并且通过将数据路由到存储设备可生成每个参数的永久记录。眼前节在任何时候都可用于外科手术和诊断测量。整个系统便于携带，可将眼球运送到多个实验站，同时保持所有压力设置和眼球位置不变。为了展示人工眼眶系统的应用，我们描述了使用该系统校准压平眼压计、研究眼内压与角膜曲率之间的关系以及环钻术和角膜缘真空固定对眼内压的影响的实验。
