Department of Cardiology, Uludağ University School of Medicine, Görükle, 16059, Bursa, Turkey,
Ir J Med Sci. 2014 Jun;183(2):297-301. doi: 10.1007/s11845-013-1009-8. Epub 2013 Aug 29.
We initially tried to study the possible correlation between the severity of coronary artery disease (CAD) and serum neopterin levels in stable coronary artery disease patients. Also we tried to investigate the neopterin as an indicator for the extent of CAD using the Gensini score.
A total of 40 patients with stable angina pectoris who are chosen for coronary angiography were selected for the study. Before the angiography procedure, blood samples were taken for the measurement of serum neopterin levels and the results of the coronary angiography were scored according to the Gensini scoring system.
Neopterin levels were correlated with the Gensini scores [p = 0.010, ρ = 0.401] and a correlation between the age of patient population and Gensini score was also observed in the study [p = 0.016, ρ = 0.380].
By the guidance of our results, we can confidently state that there is a correlation between serum neopterin levels and the severity and extent of CAD in stable coronary artery disease patients.
我们最初试图研究稳定型冠心病患者中冠状动脉疾病（CAD）严重程度与血清中新蝶呤水平之间的可能相关性。我们还试图使用 Gensini 评分来研究新蝶呤作为 CAD 程度的指标。
选择了 40 名因稳定型心绞痛而行冠状动脉造影术的患者进行了本研究。在进行冠状动脉造影术之前，采集血样以测量血清中新蝶呤水平，并根据 Gensini 评分系统对冠状动脉造影术的结果进行评分。
新蝶呤水平与 Gensini 评分呈正相关（p = 0.010，ρ = 0.401），研究中还观察到患者年龄与 Gensini 评分之间存在相关性（p = 0.016，ρ = 0.380）。
根据我们的研究结果，可以肯定地说，在稳定型冠心病患者中，血清中新蝶呤水平与 CAD 的严重程度和程度之间存在相关性。
