Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Mar Environ Res. 2013 Oct;91:41-4. doi: 10.1016/j.marenvres.2013.08.003. Epub 2013 Aug 15.
Every year thousands of new substances are synthetized and marketed. Either by regulatory demands or scientific purposes, these substances should all be tested. The determination of lethal concentration (LC) in a given population after toxicity testing in the laboratory is still the best way to establish and compare toxicity. In this technical note, we propose an R function to estimate LC with improvements on the choice of experimental design and calculation parameters, as well as in editing and spreadsheet loading. Although only LC50 values are considered herein, the same statistical considerations apply to EC50 and ED50 from quantal (dichotomous, binomial, binary) data. A running example is also provided.
每年都有成千上万的新物质被合成并推向市场。无论是出于监管要求还是科学目的，这些物质都应该进行测试。在实验室进行毒性测试后，确定特定人群中的致死浓度 (LC) 仍然是建立和比较毒性的最佳方法。在本技术说明中，我们提出了一个 R 函数来估计 LC，该函数在实验设计和计算参数的选择、编辑和电子表格加载方面进行了改进。虽然这里只考虑了 LC50 值，但同样的统计考虑也适用于来自定量（二分、二项、二进制）数据的 EC50 和 ED50。还提供了一个示例。
