[口腔及口咽晚期癌手术后的游离皮瓣重建术]
[Free flap reconstruction after oral and oropharyngeal advanced stage carcinoma surgery].
作者信息
Nao E E M, Dassonville O, Poissonnet G, Santini J, Bozec A
机构信息
Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
出版信息
Rev Stomatol Chir Maxillofac Chir Orale. 2014 Apr;115(2):70-3. doi: 10.1016/j.revsto.2013.07.013. Epub 2013 Aug 28.
INTRODUCTION
The aim of the study was to evaluate the survival and locoregional recurrence in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by surgery with free flap reconstruction followed or not by radiochemotherapy.
POPULATION AND METHODS
A retrospective study was performed on 188 patients treated by surgery with microvascular reconstruction with or without postoperative radiochemotherapy for an advanced stage squamous carcinoma of the oral cavity and/or of the oropharynx. All patients underwent free flap reconstruction. The study parameters were survival and recurrence rates.
RESULTS
The 5-year overall survival, disease specific survival, and disease free survival rates were 54%, 65%, and 61% respectively. A high level of comorbidity was the only factor that influenced the survival rate. The overall recurrence rate was 34%. Only 9% of patients having recurred were treated successfully. The survival rate after locoregional recurrence and metastasis was 6% at 2 years.
DISCUSSION
Surgery and postoperative radiochemotherapy allows for an acceptable survival rate for patients with advanced oral and oropharyngeal squamous cell carcinoma.
引言
本研究的目的是评估接受游离皮瓣重建手术且术后接受或未接受放化疗的晚期口腔和口咽鳞状细胞癌患者的生存率和局部区域复发情况。
研究对象与方法
对188例接受微血管重建手术治疗的晚期口腔和/或口咽鳞状细胞癌患者进行了回顾性研究，这些患者术后接受或未接受放化疗。所有患者均接受了游离皮瓣重建。研究参数为生存率和复发率。
结果
5年总生存率、疾病特异性生存率和无病生存率分别为54%、65%和61%。高合并症水平是影响生存率的唯一因素。总复发率为34%。复发患者中只有9%得到成功治疗。局部区域复发和转移后的2年生存率为6%。
讨论
手术及术后放化疗可为晚期口腔和口咽鳞状细胞癌患者带来可接受的生存率。
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