Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Curr Opin Plant Biol. 2013 Oct;16(5):545-53. doi: 10.1016/j.pbi.2013.08.002. Epub 2013 Aug 27.
Brassinosteroids (BRs) signal through plasma membrane-localized receptor BRI1 and other components including negatively acting BIN2 kinase to regulate BES1/BZR1 family transcription factors, which controls the expression of thousands of genes for various BR responses. Recent studies demonstrated that BR regulation of gene expression involves histone-modifying enzymes and changes of chromatin structure. Genomic experiments identified a few thousand BES1/BZR1 target genes, many of which are involved in plant growth and various signaling pathways. Moreover, BES1/BZR1 interact with many transcription factors to integrate BR and other signaling pathways. Finally, in addition to regulating BES1/BZR1, BIN2 can phosphorylate and regulate the activities of more transcription factors and signaling components, providing additional inputs of BR signaling to the BR transcriptional network and points of crosstalk with different pathways.
油菜素内酯（BRs）通过质膜定位的受体 BRI1 和其他成分（包括负调控的 BIN2 激酶）传递信号，来调节 BES1/BZR1 家族转录因子，从而控制数千个基因的表达，以响应各种 BR 信号。最近的研究表明，BR 对基因表达的调控涉及组蛋白修饰酶和染色质结构的变化。基因组实验鉴定出了几千个 BES1/BZR1 的靶基因，其中许多基因参与了植物的生长和各种信号通路。此外，BES1/BZR1 与许多转录因子相互作用，整合 BR 和其他信号通路。最后，除了调控 BES1/BZR1，BIN2 还可以磷酸化并调节更多转录因子和信号成分的活性，为 BR 转录网络提供 BR 信号的额外输入，并与不同途径进行交叉对话。
