Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar.
Lancet Oncol. 2013 Sep;14(10):e417-24. doi: 10.1016/S1470-2045(13)70165-7.
Breast cancer is a major health problem in both developing and developed countries. It is the most frequently diagnosed female malignant disease in Arab populations. The incidence of breast cancer is lower in Arab countries than in Europe and the USA but is rising fast. Breast cancers in women from Arab populations have different characteristics to those reported in individuals from Europe and the USA. For example, affected patients are at least a decade younger, they have a more advanced stage of disease at first presentation, and their tumour size is larger. Moreover, in some Arab populations, reports suggest increased axillary-lymph-node invasion, a larger proportion of negative hormone receptors, and a higher tumour grade. These disparities are not only confined to clinicopathological features but also exist at the molecular level, as shown by findings of genome-wide association studies and expression profiling.
乳腺癌是发展中国家和发达国家的一个主要健康问题。它是阿拉伯人群中最常见的女性恶性疾病。在阿拉伯国家，乳腺癌的发病率低于欧洲和美国，但正在迅速上升。来自阿拉伯人群的乳腺癌与在欧洲和美国报告的乳腺癌有不同的特征。例如，受影响的患者至少年轻十岁，在首次就诊时疾病的分期更晚，肿瘤更大。此外，在一些阿拉伯人群中，报告显示腋窝淋巴结浸润增加，阴性激素受体的比例更高，肿瘤分级更高。这些差异不仅局限于临床病理特征，在分子水平上也存在，这一点可以从全基因组关联研究和表达谱分析的结果中看出。
