抗抑郁治疗后缓解的惊恐障碍患者顶颞叶区域局部一致性的变化。
Changes in regional homogeneity of parieto-temporal regions in panic disorder patients who achieved remission with antidepressant treatment.
机构信息
Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
出版信息
J Affect Disord. 2013 Nov;151(2):709-714. doi: 10.1016/j.jad.2013.08.006. Epub 2013 Aug 19.
OBJECTIVE
This study was aimed to study the treatment effects of antidepressant for regional homogeneity (ReHo), an indicator of synchronization of brain function, in panic disorder (PD) patients.
METHOD
Twenty-one remitted PD patients with escitalopram treatment and 21 healthy controls all received 3-T magnetic resonance imaging scanning at baseline and sixth week. We utilized REST (Resting State FMRI Data Analysis Toolkit, version 1.4) to calculate regional homogeneity (ReHo) of patients and controls at baseline and sixth week. We compared the ReHo at baseline with the ReHo at sixth week to estimate the treatment effects for the ReHo of remitted patients. Besides, inter-scan effects were evaluated in the control group. The group-related differences between remitted patients and controls were also estimated.
RESULTS
Remitted PD patients had increases in ReHo of right Heschl gyrus (superior temporal lobe) and decreases in ReHo of right angular gyrus (parietal lobe). The improvements in severity of panic symptoms were negatively correlated with the changes of ReHo in right superior parietal lobe. However, remitted patients still had lower ReHo than controls in right Heschl gyrus and left thalamus.
CONCLUSION
The changes in ReHo of temporo-parietal regions might represent treatment-related ReHo changes for remission of PD. The residual alterations in ReHo of temporo-thalamic regions might represent group-related ReHo differences for patients with PD.
目的
本研究旨在探讨抗抑郁药对惊恐障碍（PD）患者脑功能同步性指标区域同质子（ReHo）的治疗效果。
方法
21 例缓解期 PD 患者接受艾司西酞普兰治疗，21 例健康对照者均在基线和第 6 周接受 3T 磁共振成像扫描。我们采用 REST（静息态 fMRI 数据分析工具包，版本 1.4）分别计算患者和对照组在基线和第 6 周的 ReHo 值。我们比较了缓解期患者基线时和第 6 周时的 ReHo 值，以评估缓解期患者 ReHo 的治疗效果。此外，我们还评估了对照组的扫描间效应。还估计了缓解期患者与对照组之间的组间差异。
结果
缓解期 PD 患者右侧 Heschl 回（颞上回）的 ReHo 值增加，右侧角回（顶叶）的 ReHo 值降低。惊恐症状严重程度的改善与右侧顶叶上回 ReHo 值的变化呈负相关。然而，缓解期患者的右侧 Heschl 回和左侧丘脑的 ReHo 值仍低于对照组。
结论
颞顶叶区域的 ReHo 变化可能代表 PD 缓解的治疗相关 ReHo 变化。颞丘脑区域的残余 ReHo 改变可能代表 PD 患者的组间 ReHo 差异。
Zotero 插件