18F-FDG PET/CT 比血清 CEA 在结直肠癌及其复发的检测中更优。
18F-FDG PET/CT superior to serum CEA in detection of colorectal cancer and its recurrence.
机构信息
Department of Diagnostic Imaging, Cross Cancer Institute, 11560 University Ave NW Edmonton, AB, T6G 1Z2, Canada.
出版信息
Clin Imaging. 2013 Nov-Dec;37(6):1094-7. doi: 10.1016/j.clinimag.2013.04.004. Epub 2013 Aug 29.
The aim of this study was to examine whether positron emission tomography (PET)/computed tomography (CT) can detect more cases of colorectal cancer (CRC) than serum carcinoembryonic antigen (CEA), both at initial staging and during surveillance for recurrence. A retrospective review of 639 CRC patients imaged with PET/CT was performed. PET/CT was superior to serum CEA in detecting CRC, identifying 2.5 times as many CRC at initial staging compared to serum CEA and 1.5 times as many CRC recurrences. The current guideline recommendations of utilizing PET/CT only in the context of a rising serum CEA will miss more than one third of all CRC recurrences.
本研究旨在探讨正电子发射断层扫描（PET）/计算机断层扫描（CT）与血清癌胚抗原（CEA）相比，在初始分期和复发监测中能否检测到更多结直肠癌（CRC）病例。对 639 例接受 PET/CT 检查的 CRC 患者进行了回顾性分析。与血清 CEA 相比，PET/CT 在检测 CRC 方面更具优势，在初始分期时可发现 2.5 倍的 CRC，在检测 CRC 复发时可发现 1.5 倍的 CRC。目前仅在血清 CEA 升高的情况下使用 PET/CT 的指南建议将遗漏超过三分之一的 CRC 复发。
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