Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
Ann Thorac Surg. 2013 Oct;96(4):1508-1516. doi: 10.1016/j.athoracsur.2013.04.096. Epub 2013 Aug 28.
Statin intake before cardiac surgery is associated with favorable outcomes. We sought to analyze the evidence for statin pretreatment before isolated coronary artery bypass graft surgery and aortic valve replacement surgery. In this meta-analysis, we demonstrate beneficial results for the endpoints mortality, stroke, atrial fibrillation, and length of stay in hospital in 36,053 statin-pretreated coronary artery bypass graft surgery patients compared with control subjects retrieved from 32 studies, but fail to detect relevant advantages through preoperative statin therapy for 3,091 patients undergoing aortic valve replacement from four trials. Strict adherence to guidelines recommending statin treatment before CABG surgery is therefore mandatory.
术前使用他汀类药物与心脏手术的良好结果相关。我们旨在分析他汀类药物预处理在孤立性冠状动脉旁路移植术和主动脉瓣置换术之前的证据。在这项荟萃分析中，我们在 32 项研究中比较了 36053 例接受他汀类药物预处理的冠状动脉旁路移植术患者与对照组患者的终点死亡率、卒、心房颤动和住院时间，结果显示他汀类药物预处理有有益的结果，但在四项试验中，对 3091 例接受主动脉瓣置换术的患者进行术前他汀类药物治疗并未发现相关优势。因此，严格遵守指南建议在 CABG 术前进行他汀类药物治疗是强制性的。
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